In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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| Lingua: | English |
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Brac University
2024
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| Accesso online: | http://hdl.handle.net/10361/24264 |
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10361-24264 |
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10361-242642024-10-01T21:02:18Z In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus Siddika, Samira Siam, Mohammad Kawsar Sharif Department of Pharmacy, Brac University Hantavirus Envelope glycoprotein HTL CTL B cell In-silico Hantavirus infections--Prevention. Hantaviruses--Vaccines. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from PDF version of thesis. Includes bibliographical references (pages 37-39). Hantavirus is a zoonotic virus which is responsible for causing hemorrhagic fever with renal syndrome & hantavirus pulmonary syndrome. But still, there is no stable vaccine developed for this virus. Developing a multiepitope vaccine candidate against this virus was the main concern of this study by using immune-informative approach. Different computational tools were used to identify the CTL, HTL & B cell epitopes for envelope surface glycoprotein. Various linkers were used to connect the epitopes with the adjuvant and construct the candidate vaccine. Physicochemical properties like - molecular weight, instability index, aliphatic index, GRAVY was also checked for the prepared vaccine. Molecular docking was done with toll-like receptor 4 (TLR-4) for checking the residual interaction. And lastly, C-ImmSim was used to evaluate the immune stimulation. Further investigation is needed to check the safety and efficacy of this vaccine candidate because checking safety & efficacy is not a part of in-silico study. Samira Siddika B. Pharmacy 2024-10-01T04:37:36Z 2024-10-01T04:37:36Z ©2024 2024-04 Thesis ID 20146058 http://hdl.handle.net/10361/24264 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 51 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Hantavirus Envelope glycoprotein HTL CTL B cell In-silico Hantavirus infections--Prevention. Hantaviruses--Vaccines. |
| spellingShingle |
Hantavirus Envelope glycoprotein HTL CTL B cell In-silico Hantavirus infections--Prevention. Hantaviruses--Vaccines. Siddika, Samira In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Siam, Mohammad Kawsar Sharif |
| author_facet |
Siam, Mohammad Kawsar Sharif Siddika, Samira |
| format |
Thesis |
| author |
Siddika, Samira |
| author_sort |
Siddika, Samira |
| title |
In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| title_short |
In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| title_full |
In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| title_fullStr |
In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| title_full_unstemmed |
In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus |
| title_sort |
in-silico based multiepitope vaccine construction of envelope glycoprotein against hantavirus |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/24264 |
| work_keys_str_mv |
AT siddikasamira insilicobasedmultiepitopevaccineconstructionofenvelopeglycoproteinagainsthantavirus |
| _version_ |
1814307895136747520 |