Sustained release solid dispersion of a BCS class II Drug
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020.
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Brac University
2021
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| Online Access: | http://hdl.handle.net/10361/14492 |
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10361-144922021-06-07T21:01:17Z Sustained release solid dispersion of a BCS class II Drug Ahmed, Fairuza Kabir, Eva Rahman Department of Pharmacy, Brac University Sustained release solid dispersion (SRSD) Dissolution BCS Class II drug Oral bioavailability This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 32-36). The present study aims to develop a sustained-release solid dispersion (SRSD) of a Biopharmaceutical Classification System (BCS) Class II drug by employing a blend of polymers. The SRSD was prepared by kneading technique, followed by solvent evaporation using rotary evaporator. After conducting an equilibrium solubility study, SRSD (F5) was found to be the optimal formulation. The dissolution profiles of SRSD (F5) were examined at different pH values. Since Carvedilol exhibits pH dependent solubility, the drug release from SRSD (F5) was limited at pH 6.8 and increased at pH 1.2. The structural characteristic of SRSD (F5) was examined by using powder X-ray diffraction (PXRD), which shows a change in drug crystallinity to an amorphous form. The results obtained from the dissolution study suggest that SRSD (F5) could be a promising approach for developing sustained-release oral dosage form of Carvedilol, thereby reducing the dosing frequency and improving the oral bioavailability. Fairuza Ahmed B. Pharmacy 2021-06-07T07:55:36Z 2021-06-07T07:55:36Z 2020 2020-03 Thesis ID: 16146002 http://hdl.handle.net/10361/14492 en_US Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 36 Pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
en_US |
| topic |
Sustained release solid dispersion (SRSD) Dissolution BCS Class II drug Oral bioavailability |
| spellingShingle |
Sustained release solid dispersion (SRSD) Dissolution BCS Class II drug Oral bioavailability Ahmed, Fairuza Sustained release solid dispersion of a BCS class II Drug |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020. |
| author2 |
Kabir, Eva Rahman |
| author_facet |
Kabir, Eva Rahman Ahmed, Fairuza |
| format |
Thesis |
| author |
Ahmed, Fairuza |
| author_sort |
Ahmed, Fairuza |
| title |
Sustained release solid dispersion of a BCS class II Drug |
| title_short |
Sustained release solid dispersion of a BCS class II Drug |
| title_full |
Sustained release solid dispersion of a BCS class II Drug |
| title_fullStr |
Sustained release solid dispersion of a BCS class II Drug |
| title_full_unstemmed |
Sustained release solid dispersion of a BCS class II Drug |
| title_sort |
sustained release solid dispersion of a bcs class ii drug |
| publisher |
Brac University |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10361/14492 |
| work_keys_str_mv |
AT ahmedfairuza sustainedreleasesoliddispersionofabcsclassiidrug |
| _version_ |
1814307640880136192 |