|
|
|
|
| LEADER |
05568pam a2200685 i 4500 |
| 001 |
AALScienceDirectebook000009 |
| 003 |
BD-DhAAL |
| 005 |
20191205134905.0 |
| 006 |
m o d |
| 007 |
cr cnu|||unuuu |
| 008 |
150928s2016 ne ob 001 0 eng d |
| 999 |
|
|
|c 41954
|d 41954
|
| 020 |
|
|
|a 0081001142
|
| 020 |
|
|
|a 9780081001141
|
| 020 |
|
|
|z 0081000944
|
| 020 |
|
|
|z 9780081000946
|
| 035 |
|
|
|a (OCoLC)922323918
|z (OCoLC)922918604
|z (OCoLC)929521751
|z (OCoLC)932328797
|z (OCoLC)951666431
|z (OCoLC)1066557439
|
| 040 |
|
|
|a BD-DhAAL
|
| 050 |
|
4 |
|a RM301.25
|
| 060 |
0 |
0 |
|a 2015 L-371
|
| 060 |
1 |
0 |
|a QV 38
|
| 072 |
|
7 |
|a MED
|x 071000
|2 bisacsh
|
| 082 |
0 |
4 |
|a 615.1901
|2 23
|
| 245 |
0 |
0 |
|a Concepts and models for drug permeability studies :
|b cell and tissue based In vitro culture models /
|c edited by Bruno Sarmento.
|h [electronic resource]
|
| 260 |
|
1 |
|a Amsterdam :
|b Elsevier,
|c 2016.
|
| 260 |
|
4 |
|c �2016
|
| 300 |
|
|
|a 1 online resource.
|
| 490 |
1 |
|
|a Woodhead Publishing series in biomedicine ;
|v number 79
|
| 500 |
|
|
|a <strong>Off-Campus Access:</strong> Athens ID and Password Required
|
| 500 |
|
|
|a <strong>On-Campus Access:</strong> No User ID or Password Required
|
| 504 |
|
|
|a Includes bibliographical references and index.
|
| 505 |
0 |
|
|a Front Cover; Related titles; Concepts and Models for Drug Permeability Studies; Copyright; Contents; List of contributors; List of figures; List of tables; 1 -- Introduction; 1.1 Introduction; References; 2 -- Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages o ...; 2.1 Introduction; 2.2 General considerations; 2.3 Drug transport; 2.3.1 Transport mechanisms; 2.4 Permeability-absorption models; 2.4.1 Physicochemical methods; 2.4.1.1 Physicochemical factors; 2.4.1.2 Immobilized artificial membrane chromatography
|
| 505 |
8 |
|
|a 2.4.1.3 Parallel artificial membrane permeability assay2.4.2 In vitro cell and tissue methods; 2.4.2.1 Cell-based methods; 2.4.2.2 Tissue-based methods; Diffusion chambers; Franz cells; Everted sacs; Isolated membrane vesicles; 2.5 Methods for permeability calculation; 2.6 Standardization of protocols for in vitro methods; 2.7 The "three Rs" principle; 2.8 Biosecurity systems; References; 3.1 -- Cell-based in vitro models for buccal permeability studies; 3.1.1 Introduction; 3.1.2 Physiology of the buccal mucosa; 3.1.3 Different in vitro models; 3.1.3.1 Hamster cheek pouch cells
|
| 505 |
8 |
|
|a 3.1.3.2 TR146 cell line3.1.3.2.1 Protocol; Cell culture conditions; Permeability studies; 3.1.3.3 Human oral keratinocytes; 3.1.3.3.1 Protocol; Oral keratinocyte culture conditions; Culturing on dead de-epidermized dermis (DDED); Permeability studies; 3.1.3.4 MatTek EpiOral"; 3.1.3.4.1 Protocol; Cell culture conditions; Permeability studies; 3.1.4 Conclusions; References; 3.2 -- Cell-based in vitro models for gastric permeability studies; 3.2.1 The stomach as a natural barrier to absorption; 3.2.2 Gastric drug delivery; 3.2.2.1 Molecular absorption in the stomach
|
| 505 |
8 |
|
|a 3.2.2.2 Physicochemical factors mediating stomach absorptive permeability3.2.3 Cellularized models of gastric permeability; 3.2.3.1 Protocol for establishing cellularized artificial models of the gastric wall; 3.2.4 Conclusions; Acknowledgments; References; 3.3 -- Cell-based in vitro models for intestinal permeability studies; 3.3.1 Anatomy and physiology of human small intestine; 3.3.1.1 Stromal-epithelial cross-talk; 3.3.2 Mechanisms of transport; 3.3.3 Intestinal barriers; 3.3.4 Intestinal in vitro models; 3.3.4.1 Caco-2 model; 3.3.4.1.1 Accelerated Caco-2 models
|
| 505 |
8 |
|
|a 3.3.4.1.2 Alternatives to the Caco-2 model3.3.4.2 Caco-2/HT29-MTX model; 3.3.4.3 Caco-2/Raji B model; 3.3.4.4 Caco-2/HT29-MTX/Raji B; 3.3.4.5 Novel 3D in vitro models; 3.3.5 Validation studies; 3.3.6 Conclusions; References; 3.4 -- Cell-based in vitro models for nasal permeability studies; 3.4.1 Introduction; 3.4.2 Nasal primary cell culture models; 3.4.2.1 Sampling approaches and procedures; 3.4.2.2 HNE cell preparation and culture initiation; 3.4.3 Immortalized nasal cell lines; 3.4.3.1 RMPI 2650 cell line; 3.4.3.2 BT cell line; 3.4.3.3 Human lung carcinoma cell line
|
| 506 |
|
|
|a Electronic access restricted to authorized BRAC University faculty, staff and students
|
| 538 |
|
|
|a Mode of access: Internet
|
| 650 |
|
0 |
|a Cell culture.
|9 38039
|
| 650 |
|
0 |
|a Drugs
|x Physiological transport
|x Research
|x Methodology.
|9 38040
|
| 650 |
|
0 |
|a Drugs
|x Testing.
|9 38041
|
| 650 |
|
0 |
|a Epithelial cells.
|9 38042
|
| 650 |
|
7 |
|a Cell culture.
|2 fast
|9 38039
|
| 650 |
|
7 |
|a Drugs
|x Testing.
|2 fast
|9 38041
|
| 650 |
|
7 |
|a Epithelial cells.
|2 fast
|9 38042
|
| 650 |
|
7 |
|a MEDICAL / Pharmacology
|2 bisacsh
|9 38043
|
| 650 |
1 |
2 |
|a Permeability.
|9 38044
|
| 650 |
1 |
2 |
|a Pharmacokinetics.
|9 38045
|
| 650 |
2 |
2 |
|a Cell Culture Techniques.
|9 38046
|
| 650 |
2 |
2 |
|a Models, Biological.
|9 38047
|
| 650 |
2 |
2 |
|a Pharmaceutical Preparations
|x metabolism.
|9 38048
|
| 650 |
2 |
2 |
|a Tissue Culture Techniques.
|9 38049
|
| 655 |
|
0 |
|a Electronic books.
|9 38050
|
| 655 |
|
4 |
|a Electronic books.
|9 38050
|
| 700 |
1 |
|
|a Sarmento, Bruno,
|e editor.
|9 38051
|
| 776 |
0 |
8 |
|i Print version:
|z 9780081000946
|z 0081000944
|w (OCoLC)911073450
|
| 830 |
|
0 |
|a Woodhead Publishing series in biomedicine ;
|v no. 79.
|9 38052
|
| 856 |
4 |
0 |
|z Full text available on ScienceDirect
|u http://www.sciencedirect.com/science/book/9780081000946
|
| 942 |
|
|
|2 ddc
|c EBK
|
| 952 |
|
|
|0 0
|1 0
|2 ddc
|4 0
|6 615_190100000000000_CON
|7 0
|9 67377
|a BRACUL
|b BRACUL
|d 2019-12-05
|l 0
|o 615.1901 CON
|r 2019-12-05
|w 2019-12-05
|y EBK
|