Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018.
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BRAC University
2018
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| Rochtain ar líne: | http://hdl.handle.net/10361/9868 |
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10361-9868 |
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10361-98682019-09-30T05:00:45Z Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave Morshed, Zarif Yasmin, Hasina Department of Pharmacy, BRAC University Maesa Montana Methanolic extract DPPH test Natural antioxidant This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. Catalogued from PDF version of project report. Includes bibliographical references (page 45-47). This research was aimed to evaluate the potential biological properties of the plant Maesa Montana for the first time. The plant belongs to the family Myrsinaceae. Maesa Montana was found to be locally used in arthritis. The methanolic extract of the leaves of the plant was partitioned with petroleum ether, carbon tetrachloride, dichloromethane and the fractionates were subjected to preliminary phytochemical screening. The phytochemical analysis showed that Maesa montana contains a mixture of phytochemicals such as alkaloids, glycosides, phenols, tannins, flavonoids, steroids and saponins. The crude methanolic extract of leaves of Maesa montana was used to evaluate the antioxidant, cytotoxic and thrombolytic activities. Antioxidant property of the extract was determined by DPPH test and the free radical scavenging activity of the crude methanolic extract was found with IC50 value of 62.27 μg/ml. The total phenolic content of the extract was found 295.395 (mg of GAE/gm of extract) suggesting a good source of natural antioxidant. The brine shrimp lethality bioassay was performed to determine the cytotoxicity of the extract. The assay showed LC50 value of 9.449 μg/ml which is comparable to the positive control (LC50 0.517 μg/ml.). In the thrombolytic study, the plant showed 19.911 % clot lysis which is also comparable to the standard clopidogrel which showed 40.436 % clot lysis. Thus our study demonstrated that the methanolic extract of leaves of Maesa montana possesses antioxidant, cytotoxic and thrombolytic activities. Zarif Morshed B. Pharmacy 2018-04-15T05:08:15Z 2018-04-15T05:08:15Z 2018 2018-02 Project report ID 13346034 http://hdl.handle.net/10361/9868 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 47 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Maesa Montana Methanolic extract DPPH test Natural antioxidant |
| spellingShingle |
Maesa Montana Methanolic extract DPPH test Natural antioxidant Morshed, Zarif Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2018. |
| author2 |
Yasmin, Hasina |
| author_facet |
Yasmin, Hasina Morshed, Zarif |
| format |
Project report |
| author |
Morshed, Zarif |
| author_sort |
Morshed, Zarif |
| title |
Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| title_short |
Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| title_full |
Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| title_fullStr |
Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| title_full_unstemmed |
Phytochemical and biological screening of methanol extract of maesa montana (Myrsinaceae) leave |
| title_sort |
phytochemical and biological screening of methanol extract of maesa montana (myrsinaceae) leave |
| publisher |
BRAC University |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/9868 |
| work_keys_str_mv |
AT morshedzarif phytochemicalandbiologicalscreeningofmethanolextractofmaesamontanamyrsinaceaeleave |
| _version_ |
1814307335439384576 |