Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels
This article was published in the Asian Pacific Journal of Tropical Biomedicine [© 2016 Hainan Medical University] and the definite version is available at : http://doi.org/10.1016/j.apjtb.2016.09.009 The Journal's website is at: https://www.sciencedirect.com/science/article/pii/S2221169116310...
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© 2016 Hainan Medical University
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10361/9477 http://doi.org/10.1016/j.apjtb.2016.09.009 |
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10361-94772018-02-15T06:35:12Z Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels Chowdhury, Sabiha Mohammad Poddar, Saikat Kumar Zaheen, Sarah Noor, Farah Ashrafi Ahmed, Najneen Haque, Sanjana Sukul, Abhijit Sunjida, Sauda Binte Mazumder, Md Mahabob Ullah Akbar, Nusrat Department of Pharmacy, BRAC University Cytotoxicity Hypoglycemia Mangifera indica Phytoconstituents This article was published in the Asian Pacific Journal of Tropical Biomedicine [© 2016 Hainan Medical University] and the definite version is available at : http://doi.org/10.1016/j.apjtb.2016.09.009 The Journal's website is at: https://www.sciencedirect.com/science/article/pii/S2221169116310887?via%3Dihub Objective To investigate the presence of different phytoconstituents in Mangifera indica (M. indica) peel and evaluate its cytotoxicity to Artemia salina and hypoglycemic potential in Swiss albino mice. Methods The methanolic extract of M. indica peel was used to determine the presence of phytoconstituents. Brine shrimp lethality bioassay method was followed to determine the cytotoxic potential of plant extract. In the case of hypoglycemic activity, oral administration of extract at 200 and 400 mg/kg and standard glibenclamide at 10 mg/kg was done, followed by determining the percentage of reduction of plasma glucose from the initial level. Results The methanolic extract of M. indica peel showed the presence of flavonoid, saponin, steroid, tannins, terpenoids, glycosides and alkaloids. In brine shrimp lethality bioassay, the LC50 of the extract and standard vincristine sulfate was found to be 2.04 and 0.41 μg/mL, respectively. After 90 and 150 min, the methanolic extract at 200 and 400 mg/kg showed prominent plasma glucose reduction of 13.95%, 22.48% and 14.16%, 26.18% respectively compared to standard glibenclamide showing 14.90% and 20.67% plasma glucose reduction. Conclusions This current research affirms prominent cytotoxic and moderate hypoglycemic potential of M. indica peel. Further bioactivity guided isolation of phytoconstituents and investigation on higher animals can lead to development of new drug molecules. Published 2018-02-15T06:32:43Z 2018-02-15T06:32:43Z 2017-01-01 Article Chowdhury, S., Poddar, S. K., Zaheen, S., Noor, F. A., Ahmed, N., Haque, S., . . . Akbar, N. (2017). Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of mangifera indica peels. Asian Pacific Journal of Tropical Biomedicine, 7(1), 49-52. 10.1016/j.apjtb.2016.09.009 22211691 http://hdl.handle.net/10361/9477 http://doi.org/10.1016/j.apjtb.2016.09.009 en https://www.sciencedirect.com/science/article/pii/S2221169116310887?via%3Dihub © 2016 Hainan Medical University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cytotoxicity Hypoglycemia Mangifera indica Phytoconstituents |
| spellingShingle |
Cytotoxicity Hypoglycemia Mangifera indica Phytoconstituents Chowdhury, Sabiha Mohammad Poddar, Saikat Kumar Zaheen, Sarah Noor, Farah Ashrafi Ahmed, Najneen Haque, Sanjana Sukul, Abhijit Sunjida, Sauda Binte Mazumder, Md Mahabob Ullah Akbar, Nusrat Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| description |
This article was published in the Asian Pacific Journal of Tropical Biomedicine [© 2016 Hainan Medical University] and the definite version is available at : http://doi.org/10.1016/j.apjtb.2016.09.009 The Journal's website is at: https://www.sciencedirect.com/science/article/pii/S2221169116310887?via%3Dihub |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Chowdhury, Sabiha Mohammad Poddar, Saikat Kumar Zaheen, Sarah Noor, Farah Ashrafi Ahmed, Najneen Haque, Sanjana Sukul, Abhijit Sunjida, Sauda Binte Mazumder, Md Mahabob Ullah Akbar, Nusrat |
| format |
Article |
| author |
Chowdhury, Sabiha Mohammad Poddar, Saikat Kumar Zaheen, Sarah Noor, Farah Ashrafi Ahmed, Najneen Haque, Sanjana Sukul, Abhijit Sunjida, Sauda Binte Mazumder, Md Mahabob Ullah Akbar, Nusrat |
| author_sort |
Chowdhury, Sabiha Mohammad |
| title |
Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| title_short |
Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| title_full |
Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| title_fullStr |
Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| title_full_unstemmed |
Phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of Mangifera indica peels |
| title_sort |
phytochemical screening and evaluation of cytotoxic and hypoglycemic properties of mangifera indica peels |
| publisher |
© 2016 Hainan Medical University |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/9477 http://doi.org/10.1016/j.apjtb.2016.09.009 |
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