Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017
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BRAC University
2018
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10361-94432019-09-30T03:14:23Z Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice Saara, Sadia Masood Yasmin, Dr. Hasina Department of Pharmacy, BRAC University Clerodendrum viscosum Hypoglycemic activity Antidiarrheal activity This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017 Cataloged from PDF version of project report. Includes bibliographical references (page 62-67). Clerodendrum viscosum is broadly distributed all through tropical and subtropical areas of the world. The leaves of the plant have been broadly utilized as antidandruff, ascaricide, antipyretic, vermifuge, purgative. Leaves are also utilized in chest with cough problems and troublesome expectoration. Here in we report the antidiarrheal and hypoglycemic activities of the methanolic root extract of Clerodendrum viscosum for the first time. In this study, the preliminary phytochemical screening of methanolic root extracts of Clerodendrum viscosum showed the presence of flavonoids, phenolic compounds, alkaloids, tannin, steroids, glycosides and coumarins. Loperamide HCl was used as the reference standard. Reduction of diarrheal feces in mice was observed by 45.4% and 63.4% at 200 and 400 mg/kg body weight, respectively in comparison to Loperamide (78.1%). The methanolic root extracts of the plant showed strong antidiarrheal activity in castor oil induced diarrhea in mice. In the determination of hypoglycaemic activity, glibenclamide was used as the standard drug. Reduction of blood glucose level was observed by 23.8% and 27.3% at 200 and 400 mg/kg body weight, respectively in comparison to glibenclamide (39.3%). The above results estimated strong hypoglycaemic activity. Thus, it can be said that the root of Clerodendrum viscosum is a potential source of drugs for antidiarrheal and antidiabetic activity. Sadia Masood Saara B. Pharmacy. 2018-02-12T10:16:29Z 2018-02-12T10:16:29Z 2017 2017-07-26 Project report ID 13146056 http://hdl.handle.net/10361/9443 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 68 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Clerodendrum viscosum Hypoglycemic activity Antidiarrheal activity |
| spellingShingle |
Clerodendrum viscosum Hypoglycemic activity Antidiarrheal activity Saara, Sadia Masood Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017 |
| author2 |
Yasmin, Dr. Hasina |
| author_facet |
Yasmin, Dr. Hasina Saara, Sadia Masood |
| format |
Project report |
| author |
Saara, Sadia Masood |
| author_sort |
Saara, Sadia Masood |
| title |
Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| title_short |
Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| title_full |
Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| title_fullStr |
Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| title_full_unstemmed |
Investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| title_sort |
investigation of antidiarrheal and hypoglycemic activities of clerodendrum viscosum root extract in mice |
| publisher |
BRAC University |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/9443 |
| work_keys_str_mv |
AT saarasadiamasood investigationofantidiarrhealandhypoglycemicactivitiesofclerodendrumviscosumrootextractinmice |
| _version_ |
1814307114660659200 |