Response surface design: optimization of a sustained release formulation of ketorolac tromethamine

This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017.

Bibliographic Details
Main Author:	Akter, Maksuda
Other Authors:	Kabir, Dr. Eva Rahman
Format:	Project report
Language:	English
Published:	BRAC University 2018
Subjects:	Ketorolac Tromethamine NSAID Musculoskeletal pain Methocel K100M CR Methocel K4M CR
Online Access:	http://hdl.handle.net/10361/9358

id	10361-9358
record_format	dspace
spelling	10361-93582019-09-30T03:12:29Z Response surface design: optimization of a sustained release formulation of ketorolac tromethamine Akter, Maksuda Kabir, Dr. Eva Rahman Department of Pharmacy, BRAC University Ketorolac Tromethamine NSAID Musculoskeletal pain Methocel K100M CR Methocel K4M CR This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017. Cataloged from PDF version of project report. Includes bibliographical references (page 60-62). The main objective of this present study is to formulate sustained release tablets of Ketorolac Tromethamine using a 32 full factorial design and to systemically optimize the drug release profile using a design expert software. Ketorolac Tromethamine is a potent NSAID drug that is used to treat moderate to severe pain, including pain after any surgery, acute musculoskeletal pain as well as pain associated with post uterine cramping. Ketorolac Tromethamine has a short biological half-life of 4-6 hours and frequent administration of the drug can cause GI problems. It is thus considered a suitable drug for doing formulation development to reduce the frequent administration of drug and also to reduce adverse effects of GI, thus making it more patient compliant and giving a constant therapeutic effect. In total, nine formulations of sustained release Ketorolac Tromethamine were prepared using different concentrations of the rate retarding polymer - Methocel K100M CR and Methocel K4M CR by direct compression. Each of the excipients were selected by performing compatibility study using Fourier transform infrared (FTIR) and Differential scanning calorimetry (DSC). In vitro dissolution study was performed for all the formulations to obtain the drug release profile of sustained release tablets of Ketorolac Tromethamine and the dissolution profile were fitted into the different kinetic models for analysis. Among all the kinetic models, most of the formulated matrix tablets followed first order drug release kinetics which indicated that the drug release follows anomalous (non-Fickian) mechanism. It was found, from the responses produced by the software, that the polymer combination used in the formulation of sustained release matrix tables at different ratios has control on the drug release. From the nine (F1-F9) formulations, F5 was finally selected as optimum formulation. Maksuda Akter B. Pharmacy. 2018-02-04T05:25:35Z 2018-02-04T05:25:35Z 2017 2017-05 Project report ID 12346009 http://hdl.handle.net/10361/9358 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 66 pages application/pdf BRAC University
institution	Brac University
collection	Institutional Repository
language	English
topic	Ketorolac Tromethamine NSAID Musculoskeletal pain Methocel K100M CR Methocel K4M CR
spellingShingle	Ketorolac Tromethamine NSAID Musculoskeletal pain Methocel K100M CR Methocel K4M CR Akter, Maksuda Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
description	This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2017.
author2	Kabir, Dr. Eva Rahman
author_facet	Kabir, Dr. Eva Rahman Akter, Maksuda
format	Project report
author	Akter, Maksuda
author_sort	Akter, Maksuda
title	Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
title_short	Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
title_full	Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
title_fullStr	Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
title_full_unstemmed	Response surface design: optimization of a sustained release formulation of ketorolac tromethamine
title_sort	response surface design: optimization of a sustained release formulation of ketorolac tromethamine
publisher	BRAC University
publishDate	2018
url	http://hdl.handle.net/10361/9358
work_keys_str_mv	AT aktermaksuda responsesurfacedesignoptimizationofasustainedreleaseformulationofketorolactromethamine
_version_	1814307114323017728

Response surface design: optimization of a sustained release formulation of ketorolac tromethamine

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