Development of dissolution medium of poorly soluble drug by using surfactants
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2015.
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BRAC Univeristy
2018
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| Online-ссылка: | http://hdl.handle.net/10361/9140 |
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10361-91402019-09-30T03:27:48Z Development of dissolution medium of poorly soluble drug by using surfactants Shoaib, Syed Hasan Mahamud Sharmin, Shahana Department of Pharmacy, BRAC University British pharmacopeia Drug Carbamazepine This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2015. Cataloged from PDF version of project report. Includes bibliographical references (page 60-64). The drug dissolution from its dosage form is considered as an important parameter in the absorption. Drugs which are fairly soluble in gastrointestinal (GI) media exhibit complete oral absorption leading to better bioavailability. For BCS class II drug, solubility is a crucial rate limiting factor to achieve its desired level in systemic circulation for pharmacological response. In this review article, study shown to improve the drug solubility by adding surfactant into the dissolution media. Especially we have found the solubility data on the drugs having low solubility like Glipizide, Carvedilol, Carbamazepine, Mefenamic acid, Simvaststin, Candesartan Cilexetil and Ibuprofen. For the improvement of their dissolution medium surfactants like SLS, Tween 80, SDS are being used. For Glipizide, Carvedilol, pure Carbamazepine, CBZ–NIC co crystal and the physical mixtures of CBZ III and NIC, Simvastatin, Mefenamic acid, Ibuprofen and Candesartan Cilexetil the highest solubility was found in the medium containing 0.75% SLS in phosphate buffer pH 6.8, 3% SLS in water and 3% SLS in 0.1 N HCL, 10.4 mM SLS in water, 0.1% SLS in water, 2% w/v of SLS, 0.1% SDS in phosphate buffer pH 7.2 and 0.35% w/v Tween 20 in phosphate buffer pH 6.5 respectively. Syed Hasan Mahamud Shoaib B. Pharmacy 2018-01-23T04:20:10Z 2018-01-23T04:20:10Z 2015 2015-08 Project report ID 11146001 http://hdl.handle.net/10361/9140 en BRAC University project reports are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 64 pages application/pdf BRAC Univeristy |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
British pharmacopeia Drug Carbamazepine |
| spellingShingle |
British pharmacopeia Drug Carbamazepine Shoaib, Syed Hasan Mahamud Development of dissolution medium of poorly soluble drug by using surfactants |
| description |
This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2015. |
| author2 |
Sharmin, Shahana |
| author_facet |
Sharmin, Shahana Shoaib, Syed Hasan Mahamud |
| format |
Project report |
| author |
Shoaib, Syed Hasan Mahamud |
| author_sort |
Shoaib, Syed Hasan Mahamud |
| title |
Development of dissolution medium of poorly soluble drug by using surfactants |
| title_short |
Development of dissolution medium of poorly soluble drug by using surfactants |
| title_full |
Development of dissolution medium of poorly soluble drug by using surfactants |
| title_fullStr |
Development of dissolution medium of poorly soluble drug by using surfactants |
| title_full_unstemmed |
Development of dissolution medium of poorly soluble drug by using surfactants |
| title_sort |
development of dissolution medium of poorly soluble drug by using surfactants |
| publisher |
BRAC Univeristy |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/9140 |
| work_keys_str_mv |
AT shoaibsyedhasanmahamud developmentofdissolutionmediumofpoorlysolubledrugbyusingsurfactants |
| _version_ |
1814309029759942656 |