Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
This article was published in the BMC Infectious Diseases [© Jaenisch et al. 2016] and the definite version is available at : https://doi.org/10.1186/s12879-016-1440-3 . The Journal's website is at: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1440-3
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| বিন্যাস: | প্রবন্ধ |
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/10361/8890 https://doi.org/10.1186/s12879-016-1440-3 |
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10361-88902019-09-30T03:34:00Z Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries Jaenisch, Thomas Hoai Tam, Dong Thi Thanh Kieu, Nguyen Tan Ngoc, Tran Van Tran Nam, Nguyen Kinh, Nguyen Van Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun Chai See, Lucy Lum Sathar, Jameela Sandoval, Ernesto Pleités Marón Alfaro, Gabriela Maria Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget Dengue Severe disease Risk prediction This article was published in the BMC Infectious Diseases [© Jaenisch et al. 2016] and the definite version is available at : https://doi.org/10.1186/s12879-016-1440-3 . The Journal's website is at: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1440-3 Background The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course. Method/Design This is a prospective multi-centre observational study aiming to enrol 7–8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later. Discussion Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for “Integrated Management of Childhood Illness” used in dengue-endemic countries. Published 2018-01-03T06:27:51Z 2018-01-03T06:27:51Z 2016-02-18 Article Jaenisch, T., Tam, D. T. H., Kieu, N. T. T., Van Ngoc, T., Nam, N. T., Van Kinh, N., … Wills, B. (2016). Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC Infectious Diseases, 16(1), 120. https://doi.org/10.1186/s12879-016-1440-3 14712334 http://hdl.handle.net/10361/8890 https://doi.org/10.1186/s12879-016-1440-3 en https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1440-3 application/pdf © 2016 BMC Infectious Diseases |
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Brac University |
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Institutional Repository |
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English |
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Dengue Severe disease Risk prediction |
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Dengue Severe disease Risk prediction Jaenisch, Thomas Hoai Tam, Dong Thi Thanh Kieu, Nguyen Tan Ngoc, Tran Van Tran Nam, Nguyen Kinh, Nguyen Van Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun Chai See, Lucy Lum Sathar, Jameela Sandoval, Ernesto Pleités Marón Alfaro, Gabriela Maria Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| description |
This article was published in the BMC Infectious Diseases [© Jaenisch et al. 2016] and the definite version is available at : https://doi.org/10.1186/s12879-016-1440-3 . The Journal's website is at: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1440-3 |
| format |
Article |
| author |
Jaenisch, Thomas Hoai Tam, Dong Thi Thanh Kieu, Nguyen Tan Ngoc, Tran Van Tran Nam, Nguyen Kinh, Nguyen Van Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun Chai See, Lucy Lum Sathar, Jameela Sandoval, Ernesto Pleités Marón Alfaro, Gabriela Maria Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget |
| author_facet |
Jaenisch, Thomas Hoai Tam, Dong Thi Thanh Kieu, Nguyen Tan Ngoc, Tran Van Tran Nam, Nguyen Kinh, Nguyen Van Yacoub, Sophie Chanpheaktra, Ngoun Kumar, Varun Chai See, Lucy Lum Sathar, Jameela Sandoval, Ernesto Pleités Marón Alfaro, Gabriela Maria Laksono, Ida Safitri Mahendradhata, Yodi Sarker, Malabika Ahmed, Firoz Caprara, Andrea Benevides, Bruno Souza Marques, Ernesto T. A. Magalhaes, Tereza Brasil, Patricia Netto, Marco Tami, Adriana Bethencourt, Sarah E. Guzman, Maria Simmons, Cameron Quyen, Nguyen Thanh Ha Merson, Laura Dung, Nguyen Thi Phuong Beck, Dorothea Wirths, Marius Wolbers, Marcel Lam, Phung Khanh Rosenberger, Kerstin Wills, Bridget |
| author_sort |
Jaenisch, Thomas |
| title |
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| title_short |
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| title_full |
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| title_fullStr |
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| title_full_unstemmed |
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| title_sort |
clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries |
| publisher |
© 2016 BMC Infectious Diseases |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10361/8890 https://doi.org/10.1186/s12879-016-1440-3 |
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