Optimization of a formulation of ketorolac tromethamine using DoE
This project report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016.
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| Lenguaje: | English |
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BRAC Univeristy
2017
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| Acceso en línea: | http://hdl.handle.net/10361/8355 |
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10361-8355 |
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10361-83552019-09-30T03:07:00Z Optimization of a formulation of ketorolac tromethamine using DoE Erina, Ishrat Naher Kabir, Dr. Eva Rahman Department of Pharmacy, BRAC University Ketorolac tromethamine Drug This project report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016. Cataloged from PDF version of project report. Includes bibliographical references (page 58-59). The oral sustained release drug delivery system is often considered as one of the most convenient forms of drug administration over conventional dosage forms due to its ability to maintain an effective therapeutic efficacy and contribution to rational drug therapy. As the sustained release dosage form allows slow release of the drug and maintains the constant therapeutic blood or tissue drug level for an extended period of time, it is one of the most widely used drug delivery systems. The main purpose of using the sustained release dosage form is to decrease frequency of drug intake, thus reducing adverse effects associated with the drug and also to ensure better patient compliance. The aim of the present study was to formulate an optimum formulation of the sustained release oral tablet dosage form of Ketorolac Tromethamine. Since Ketorolac Tromethamine has a short biological half-life, it can be considered to formulate as a sustained release dosage form in order to reduce the dosing regimen and subside the gastrointestinal adverse effects that is likely to occur from its frequent consumption. For the purpose of formulation design, nine formulations have been designed for 200 mg and 250 mg matrix tablets each. The different polymer ratio employed to formulate the tablet shows the impact on drug release from the dosage form. The excipients for the formulations have been selected based on the FT-IR and DSC study that justifies the compatibility of excipients with the API. The dissolution study has been done for all designed formulations in order to get the drug release profile at different time interval and these release profiles have been placed into different mathematical release kinetic models in order to get the best fitted model for release rate. Finally, the optimum formulation for the two different doses was determined using Design Expert Software which was F5 for 200 mg of Ketorolac Tromethamine matrix tablets. Ishrat Naher Erina B. Pharmacy 2017-07-25T04:51:48Z 2017-07-25T04:51:48Z 2016 2016-10 Project report ID 12346008 http://hdl.handle.net/10361/8355 en BRAC University project report are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. BRAC University project report are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 59 pages application/pdf BRAC Univeristy |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Ketorolac tromethamine Drug |
| spellingShingle |
Ketorolac tromethamine Drug Erina, Ishrat Naher Optimization of a formulation of ketorolac tromethamine using DoE |
| description |
This project report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016. |
| author2 |
Kabir, Dr. Eva Rahman |
| author_facet |
Kabir, Dr. Eva Rahman Erina, Ishrat Naher |
| format |
Project report |
| author |
Erina, Ishrat Naher |
| author_sort |
Erina, Ishrat Naher |
| title |
Optimization of a formulation of ketorolac tromethamine using DoE |
| title_short |
Optimization of a formulation of ketorolac tromethamine using DoE |
| title_full |
Optimization of a formulation of ketorolac tromethamine using DoE |
| title_fullStr |
Optimization of a formulation of ketorolac tromethamine using DoE |
| title_full_unstemmed |
Optimization of a formulation of ketorolac tromethamine using DoE |
| title_sort |
optimization of a formulation of ketorolac tromethamine using doe |
| publisher |
BRAC Univeristy |
| publishDate |
2017 |
| url |
http://hdl.handle.net/10361/8355 |
| work_keys_str_mv |
AT erinaishratnaher optimizationofaformulationofketorolactromethamineusingdoe |
| _version_ |
1814307042740928512 |