Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D
This article was published in the Journal of Health, Population and Nutrition [© 2014 International Center for Diarrhoeal Disease Research] and The Journal's website is at: https://www.ncbi.nlm.nih.gov/pubmed/25895202
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© 2014 International Center for Diarrhoeal Disease Research
2017
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10361-75902017-01-12T04:22:23Z Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D Islam, Md Zahirul Shamim, Abu Ahmed Viljakainen, Heli T Lamberg-Allardt, Christel Jehan, Atia H Khan, Habib Ullah Al-Arif, Ferdaus Ahmad Akhtaruzzaman, Mohammad James P Grant School of Public Health, BRAC University Female garment workers HDL-cholesterol LDL-cholesterol Total cholesterol Triacylglycerol Vitamin D intervention Bangladesh This article was published in the Journal of Health, Population and Nutrition [© 2014 International Center for Diarrhoeal Disease Research] and The Journal's website is at: https://www.ncbi.nlm.nih.gov/pubmed/25895202 Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention. Published 2017-01-11T09:27:08Z 2017-01-11T09:27:08Z 2014 Article Islam, M. Z., Shamim, A. A., Akhtaruzzaman, M., Kärkkäinen, M., & Lamberg-Allardt, C. (2014). Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal bangladeshi garment factory workers with hypovitaminosis D. Journal of Health, Population and Nutrition, 32(4), 687-695. 16060997 http://hdl.handle.net/10361/7590 en https://www.ncbi.nlm.nih.gov/pubmed/25895202 © 2014 International Center for Diarrhoeal Disease Research |
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Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Female garment workers HDL-cholesterol LDL-cholesterol Total cholesterol Triacylglycerol Vitamin D intervention Bangladesh |
| spellingShingle |
Female garment workers HDL-cholesterol LDL-cholesterol Total cholesterol Triacylglycerol Vitamin D intervention Bangladesh Islam, Md Zahirul Shamim, Abu Ahmed Viljakainen, Heli T Lamberg-Allardt, Christel Jehan, Atia H Khan, Habib Ullah Al-Arif, Ferdaus Ahmad Akhtaruzzaman, Mohammad Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| description |
This article was published in the Journal of Health, Population and Nutrition [© 2014 International Center for Diarrhoeal Disease Research] and The Journal's website is at: https://www.ncbi.nlm.nih.gov/pubmed/25895202 |
| author2 |
James P Grant School of Public Health, BRAC University |
| author_facet |
James P Grant School of Public Health, BRAC University Islam, Md Zahirul Shamim, Abu Ahmed Viljakainen, Heli T Lamberg-Allardt, Christel Jehan, Atia H Khan, Habib Ullah Al-Arif, Ferdaus Ahmad Akhtaruzzaman, Mohammad |
| format |
Article |
| author |
Islam, Md Zahirul Shamim, Abu Ahmed Viljakainen, Heli T Lamberg-Allardt, Christel Jehan, Atia H Khan, Habib Ullah Al-Arif, Ferdaus Ahmad Akhtaruzzaman, Mohammad |
| author_sort |
Islam, Md Zahirul |
| title |
Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| title_short |
Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| title_full |
Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| title_fullStr |
Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| title_full_unstemmed |
Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D |
| title_sort |
effect of vitamin d, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal bangladeshi garment factory workers with hypovitaminosis d |
| publisher |
© 2014 International Center for Diarrhoeal Disease Research |
| publishDate |
2017 |
| url |
http://hdl.handle.net/10361/7590 |
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