In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

Detalhes bibliográficos
Principais autores:	Sayeed, Mohammed Aktar, Hasan, S. M. Raquibul, Rana, Md Sohel
Outros Autores:	Department of Pharmacy, BRAC University
Formato:	Atigo
Idioma:	English
Publicado em:	© 2011 Latin American Journal of Pharmacy 2016
Assuntos:	Ardon's mehod Job's method Ketotifen Metformin Stability constant
Acesso em linha:	http://hdl.handle.net/10361/7157

id	10361-7157
record_format	dspace
spelling	10361-71572016-12-07T06:56:13Z In vitro study on interaction of ketotifen fumarate with metformin hydrochloride Sayeed, Mohammed Aktar Hasan, S. M. Raquibul Rana, Md Sohel Department of Pharmacy, BRAC University Ardon's mehod Job's method Ketotifen Metformin Stability constant This article was published in Latin American Journal of Pharmacy [© 2011 Latin American Journal of Pharmacy] and the definite version is available at: https://goo.gl/XOJ7tm The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement. Job's analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon's plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo. Published 2016-12-07T06:52:34Z 2016-12-07T06:52:34Z 2011 Article Sayeed, M. A., Hasan, S. M. R., & Rana, M. S. (2011). In vitro study on interaction of ketotifen fumarate with metformin hydrochloride. Latin American Journal of Pharmacy, 30(1), 189 03262383 http://hdl.handle.net/10361/7157 en https://goo.gl/XOJ7tm © 2011 Latin American Journal of Pharmacy
institution	Brac University
collection	Institutional Repository
language	English
topic	Ardon's mehod Job's method Ketotifen Metformin Stability constant
spellingShingle	Ardon's mehod Job's method Ketotifen Metformin Stability constant Sayeed, Mohammed Aktar Hasan, S. M. Raquibul Rana, Md Sohel In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
description	This article was published in Latin American Journal of Pharmacy [© 2011 Latin American Journal of Pharmacy] and the definite version is available at: https://goo.gl/XOJ7tm
author2	Department of Pharmacy, BRAC University
author_facet	Department of Pharmacy, BRAC University Sayeed, Mohammed Aktar Hasan, S. M. Raquibul Rana, Md Sohel
format	Article
author	Sayeed, Mohammed Aktar Hasan, S. M. Raquibul Rana, Md Sohel
author_sort	Sayeed, Mohammed Aktar
title	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_short	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_full	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_fullStr	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_full_unstemmed	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_sort	in vitro study on interaction of ketotifen fumarate with metformin hydrochloride
publisher	© 2011 Latin American Journal of Pharmacy
publishDate	2016
url	http://hdl.handle.net/10361/7157
work_keys_str_mv	AT sayeedmohammedaktar invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride AT hasansmraquibul invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride AT ranamdsohel invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride
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In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

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