In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb
This article was published in Global Journal of Pharmacology [© IDOSI Publications, 2011] and the definite version is available at: https://idosi.org/gjp/5(1)11/6.pdf
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© IDOSI Publications, 2011
2016
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| Διαθέσιμο Online: | http://hdl.handle.net/10361/7133 |
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10361-71332016-12-06T10:06:21Z In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb Chowdhury, Nargis S Alam, Md. Badrul Haque, A S M Tanbirul Zahan, Ronok Ehsanul, M Mazumder, Haque Haque, M Ekramul Department of Pharmacy, BRAC University Free radical Thrombolysis Toxicity This article was published in Global Journal of Pharmacology [© IDOSI Publications, 2011] and the definite version is available at: https://idosi.org/gjp/5(1)11/6.pdf Investigation with the crude methanolic extract of Aponogeton undulatus was carried out to evaluate its possible antioxidant and thrombolysis activity. In DPPH free radical scavenging assay, the extract exhibited potent antioxidant activity with a IC50 values of 2.43±1.06 μg/ml while in ascorbic acid, the value become 50 2.14±0.11 μg/ml. In thrombolytic activity using in vitro clot lysis assay method, the crude methanolic extract was found to have significant (p<0.001) thrombolytic activity at a dose of 10 mg/ml with a miximum effect of 20.23±1.56% while the standard streptokinase showed 46.13±3.87%. The extract was also investigated for its antibacterial and toxic potentiality using agar diffusion and Brine Shrimp lethality bioassay, respectively. The highest antibacterial effect was shown against Bacillus cereus (zone of inhibition 12±0.65 mm) followed by Escherichia coli (zone of inhibition 10±0.71 mm). In this bioassay the extract showed significant toxicity to Brine Shrimp nauplii with the LC50 value of 2.24±0.98 μg/ml. The study clearly indicated that the extract 50 possesses good antioxidant and thromolytic activity along with broad spectrum antibacterial and toxic potentiality. Published 2016-12-06T10:00:19Z 2016-12-06T10:00:19Z 2011 Article Chowdhury, N. S., Alam, M. B., Tanbirul Haque, A. S. M., Zahan, R., Mazumder, M. E. H., & Haque, M. E. (2011). In vitro free radical scavenging and thrombolytic activities of bangladeshi aquatic plant aponogeton undulatus roxb. Global Journal of Pharmacology, 5(1), 27-32 19920075 http://hdl.handle.net/10361/7133 en https://idosi.org/gjp/5(1)11/6.pdf © IDOSI Publications, 2011 |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
Free radical Thrombolysis Toxicity |
| spellingShingle |
Free radical Thrombolysis Toxicity Chowdhury, Nargis S Alam, Md. Badrul Haque, A S M Tanbirul Zahan, Ronok Ehsanul, M Mazumder, Haque Haque, M Ekramul In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| description |
This article was published in Global Journal of Pharmacology [© IDOSI Publications, 2011] and the definite version is available at: https://idosi.org/gjp/5(1)11/6.pdf |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Chowdhury, Nargis S Alam, Md. Badrul Haque, A S M Tanbirul Zahan, Ronok Ehsanul, M Mazumder, Haque Haque, M Ekramul |
| format |
Article |
| author |
Chowdhury, Nargis S Alam, Md. Badrul Haque, A S M Tanbirul Zahan, Ronok Ehsanul, M Mazumder, Haque Haque, M Ekramul |
| author_sort |
Chowdhury, Nargis S |
| title |
In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| title_short |
In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| title_full |
In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| title_fullStr |
In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| title_full_unstemmed |
In vitro free radical scavenging and thrombolytic activities of Bangladeshi aquatic plant Aponogeton undulatus Roxb |
| title_sort |
in vitro free radical scavenging and thrombolytic activities of bangladeshi aquatic plant aponogeton undulatus roxb |
| publisher |
© IDOSI Publications, 2011 |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7133 |
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