Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate
This article was published in Journal of Pharmacology and Toxicology [© 2011 Academic Journals Inc.] and the definite version is available at: http://docsdrive.com/pdfs/academicjournals/jpt/0000/28817-28817.pdf
| Príomhchruthaitheoirí: | , , , , , , , , |
|---|---|
| Rannpháirtithe: | |
| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
© 2011 Academic Journals Inc.
2016
|
| Ábhair: | |
| Rochtain ar líne: | http://hdl.handle.net/10361/7126 http://doi.org/10.3923/jpt.2011.468.480 |
| id |
10361-7126 |
|---|---|
| record_format |
dspace |
| spelling |
10361-71262016-12-06T07:37:22Z Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate Hossain, M.S. Alam, M.B. Chowdhury, N.S. Asadujjaman, M. Zahan, R. Islam, M.M. Mazumder, M.E.H. Haque, M.E. Islam, A. Department of Pharmacy, BRAC University Eclipta prostrata Free radical Inflammation This article was published in Journal of Pharmacology and Toxicology [© 2011 Academic Journals Inc.] and the definite version is available at: http://docsdrive.com/pdfs/academicjournals/jpt/0000/28817-28817.pdf The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO- (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.98±0.08, 45.98±0.07 and 14.45±0.18 μg mL-1 for DPPH, NO and ONOO- assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg-1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agent Published 2016-12-06T07:34:49Z 2016-12-06T07:34:49Z 2011 Article Hossain, M. S., Alam, M. B., Chowdhury, N. S., Asadujjaman, M., Zahan, R., Islam, M. M., . . . Islam, A. (2011). Antioxidant, analgesic and anti-inflammatory activities of the herb eclipta prostrate. Journal of Pharmacology and Toxicology, 6(5), 468-480. doi:10.3923/jpt.2011.468.480 1816496X http://hdl.handle.net/10361/7126 http://doi.org/10.3923/jpt.2011.468.480 en http://docsdrive.com/pdfs/academicjournals/jpt/0000/28817-28817.pdf © 2011 Academic Journals Inc. |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Eclipta prostrata Free radical Inflammation |
| spellingShingle |
Eclipta prostrata Free radical Inflammation Hossain, M.S. Alam, M.B. Chowdhury, N.S. Asadujjaman, M. Zahan, R. Islam, M.M. Mazumder, M.E.H. Haque, M.E. Islam, A. Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| description |
This article was published in Journal of Pharmacology and Toxicology [© 2011 Academic Journals Inc.] and the definite version is available at: http://docsdrive.com/pdfs/academicjournals/jpt/0000/28817-28817.pdf |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Hossain, M.S. Alam, M.B. Chowdhury, N.S. Asadujjaman, M. Zahan, R. Islam, M.M. Mazumder, M.E.H. Haque, M.E. Islam, A. |
| format |
Article |
| author |
Hossain, M.S. Alam, M.B. Chowdhury, N.S. Asadujjaman, M. Zahan, R. Islam, M.M. Mazumder, M.E.H. Haque, M.E. Islam, A. |
| author_sort |
Hossain, M.S. |
| title |
Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| title_short |
Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| title_full |
Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| title_fullStr |
Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| title_full_unstemmed |
Antioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrate |
| title_sort |
antioxidant, analgesic and anti-inflammatory activities of the herb eclipta prostrate |
| publisher |
© 2011 Academic Journals Inc. |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7126 http://doi.org/10.3923/jpt.2011.468.480 |
| work_keys_str_mv |
AT hossainms antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT alammb antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT chowdhuryns antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT asadujjamanm antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT zahanr antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT islammm antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT mazumdermeh antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT haqueme antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate AT islama antioxidantanalgesicandantiinflammatoryactivitiesoftheherbecliptaprostrate |
| _version_ |
1814307464508604416 |