Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions
This article was published in the Ars Pharmaceutica [© 2012 Ars Pharmaceutica] The Journal's website is at: http://farmacia.ugr.es/ars/ars_web/controldescargas.php?763.
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© 2012 Ars Pharmaceutica
2016
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| Online dostop: | http://hdl.handle.net/10361/7093 |
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10361-70932016-12-04T10:56:11Z Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions Shihab-us-Sakib, Khondoker Islam, Mohammad A. Moniruzzaman, M. Hussein, Anwar Hossain, M. Mahboob Mazid, Mohammad A. Department of Mathematics and Natural Sciences, BRAC University Atenolol Bovine serum albumin Desloratadine Drug-drug interaction Equilibrium dialysis This article was published in the Ars Pharmaceutica [© 2012 Ars Pharmaceutica] The Journal's website is at: http://farmacia.ugr.es/ars/ars_web/controldescargas.php?763. Aims: The binding of atenolol a selective β1 receptor antagonist and desloratadine, an H1 receptor antagonist, to bovine serum albumin. Methods: The analysis of binding was studied by equilibrium dialysis method (ED) using ranitidine and diazepam as site-1 and site-2 specific probe, respectively. Results: The study suggested two sets of association constants, for atenolol: high affinity association constant (k1 = 5 × 10-5 M-1) with low capacity (n1 = 2) and low affinity association constant (k2 = 2.5 × 10-5 M-1) with high capacity (n2 = 5), while for desloratadine: high affinity association constant (k1 = 45 × 10-5 M-1) with low capacity (n1 = 1.3) and low affinity association constant (k 2 = 5 × 10-5 M-1) with high capacity (n2 = 2.5) at pH 7.4 and 27 °C. During concurrent administration of atenolol and desloratadine in presence or absence of ranitidine or diazepam, desloratadine causes the release of atenolol from its binding site on BSA resulting reduced binding of atenolol to BSA. The increment in free fraction of atenolol was from 84.01% to 99 % upon the addition of increased concentration of only desloratadine at a concentration of 0 × 10-5 M to 14 × 10 -5 M. In presence of diazepam as site-II specific probes, desloratadine further increases the free fraction of atenolol was from 0.45% to 14.3%. Conclusion: These data were indicative for the interaction of higher concentration of desloratadine at the binding sites on BSA changing the pharmacokinetics properties of atenolol. Published 2016-12-04T06:00:53Z 2016-12-04T06:00:53Z 2012 Article Shihab-Us-Sakib, K., Islam, M. A., Moniruzzaman, M., Hussein, A., Mahboob Hossain, M., & Mazid, M. A. (2012). Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions. Ars Pharmaceutica, 53(4), 21-27. 00042927 http://hdl.handle.net/10361/7093 en http://farmacia.ugr.es/ars/ars_web/controldescargas.php?763. © 2012 Ars Pharmaceutica |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Atenolol Bovine serum albumin Desloratadine Drug-drug interaction Equilibrium dialysis |
| spellingShingle |
Atenolol Bovine serum albumin Desloratadine Drug-drug interaction Equilibrium dialysis Shihab-us-Sakib, Khondoker Islam, Mohammad A. Moniruzzaman, M. Hussein, Anwar Hossain, M. Mahboob Mazid, Mohammad A. Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| description |
This article was published in the Ars Pharmaceutica [© 2012 Ars Pharmaceutica] The Journal's website is at: http://farmacia.ugr.es/ars/ars_web/controldescargas.php?763. |
| author2 |
Department of Mathematics and Natural Sciences, BRAC University |
| author_facet |
Department of Mathematics and Natural Sciences, BRAC University Shihab-us-Sakib, Khondoker Islam, Mohammad A. Moniruzzaman, M. Hussein, Anwar Hossain, M. Mahboob Mazid, Mohammad A. |
| format |
Article |
| author |
Shihab-us-Sakib, Khondoker Islam, Mohammad A. Moniruzzaman, M. Hussein, Anwar Hossain, M. Mahboob Mazid, Mohammad A. |
| author_sort |
Shihab-us-Sakib, Khondoker |
| title |
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| title_short |
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| title_full |
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| title_fullStr |
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| title_full_unstemmed |
Binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| title_sort |
binding of desloratadine and atenolol with bovine serum albumin and their in-vitro interactions |
| publisher |
© 2012 Ars Pharmaceutica |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7093 |
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