Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant
This article was published in Pharmacognosy Journal [© 2011 Pharmacognosy Journal] and the definite version is available at: https://goo.gl/4T47PD
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© 2011 Pharmacognosy Journal
2016
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10361-70752016-12-04T08:21:49Z Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant Zahan, Ronok Ripa, Farhana Alam Alam, M. Badrul Haque, M. Anamul Mosaddik, M.A. Nahar, Laizuman Department of Pharmacy, BRAC University Alloxan Antioxidant activity Marsilea quadrifolia Metformin hydrocloride This article was published in Pharmacognosy Journal [© 2011 Pharmacognosy Journal] and the definite version is available at: https://goo.gl/4T47PD Introduction: Oxidative stress induced by alloxan has been shown to damage pancreatic beta cell and produce hyperglycemia in rats. Hence the present investigation has designed to appraise antidiabetic and antioxidant principle of the methanolic extract of Marsilea quadrifolia (MEMQ). Methods: Hypoglycemic effect was evaluated in alloxan induced diabetic rat. The oral administration of plant extract at a dose of 300 mg/kg body weight was given to fasting glucose loaded rat with regard to normal control during 1 hr. study period and in alloxan induced (110 mg/kg body weight i.p.) diabetic rat in comparison with reference drug Metformin Hydrochloride (100 mg/kg) during 3 days study period. The antioxidant potential of MEMQ was checked by qualitative method and quantitatively through DPPH(1,1- diphenyl-2-picryl-hydrazyl) scavenging assay at 517 nm. Total phenolic content, total antioxidant capacity and reducing power activity was also assayed. Results: Considerable drop in elevated blood glucose level was observed in the alloxan induced diabetic (p<0.05 & p<0.001) rat. At a dose of 300 mg/kg the extract showed glucose level reduction of 47.57% in alloxan induced rat while 44.38% was found for Metformin after 3 days. Antioxidant activity using DPPH was found to increase in a concentration dependent manner with an IC 50 value of 96.37 ± 3.62μg/ml higher than the standard one, IC 50 16.59±0.59μg/ml. Total phenolic content was found 165.75 ± 0.961 mg/g in GAE and the total antioxidant capacity was equivalents of ascorbic acid (224.90 ± 1.42 mg/g). Conclusions: In all ways the extract showed significant antidiabetic and antioxidative potency. The present investigation suggests that MEMQ may be a potential source of natural antioxidant with good hypoglycemic activity. Published 2016-12-01T10:13:54Z 2016-12-01T10:13:54Z 2011-10 Article Zahan, R., Ripa, F. A., Alam, M. B., Haque, M. A., Mosaddik, M. A., & Nahar, L. (2011). Hypoglycemic and in vitro antioxidant effects of methanolic extract of marsilea quadrifolia plant. Pharmacognosy Journal, 3(26), 86-92. doi:10.5530/pj.2011.26.14 09753575 http://hdl.handle.net/10361/7075 10.5530/pj.2011.26.14 en https://goo.gl/4T47PD © 2011 Pharmacognosy Journal |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Alloxan Antioxidant activity Marsilea quadrifolia Metformin hydrocloride |
| spellingShingle |
Alloxan Antioxidant activity Marsilea quadrifolia Metformin hydrocloride Zahan, Ronok Ripa, Farhana Alam Alam, M. Badrul Haque, M. Anamul Mosaddik, M.A. Nahar, Laizuman Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| description |
This article was published in Pharmacognosy Journal [© 2011 Pharmacognosy Journal] and the definite version is available at: https://goo.gl/4T47PD |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Zahan, Ronok Ripa, Farhana Alam Alam, M. Badrul Haque, M. Anamul Mosaddik, M.A. Nahar, Laizuman |
| format |
Article |
| author |
Zahan, Ronok Ripa, Farhana Alam Alam, M. Badrul Haque, M. Anamul Mosaddik, M.A. Nahar, Laizuman |
| author_sort |
Zahan, Ronok |
| title |
Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| title_short |
Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| title_full |
Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| title_fullStr |
Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| title_full_unstemmed |
Hypoglycemic and in vitro antioxidant effects of methanolic extract of Marsilea quadrifolia Plant |
| title_sort |
hypoglycemic and in vitro antioxidant effects of methanolic extract of marsilea quadrifolia plant |
| publisher |
© 2011 Pharmacognosy Journal |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7075 |
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