Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora
This article was published in Pharmacognosy Journal [© 2012 Elsevier Ltd.] and the definite version is available at http://www.sciencedirect.com/science/article/pii/S0975357512800824 The article website is at: http://www.sciencedirect.com/science/journal/09753575/4
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© 2012 Elsevier Ltd.
2016
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10361-70112016-12-04T08:23:40Z Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora Nahar, Laizuman, Zahan, Ronok Ibn Morshed, Mahmud Tareq Haque, Anamul Alam, Zahangir Mosaddik, Ashik Department of Pharmacy, BRAC University Synedrella nodiflora Antioxidant Free radical Analgesic activity CNS depressant This article was published in Pharmacognosy Journal [© 2012 Elsevier Ltd.] and the definite version is available at http://www.sciencedirect.com/science/article/pii/S0975357512800824 The article website is at: http://www.sciencedirect.com/science/journal/09753575/4 Synedrella nodiflora (L) Gaertn. belonging to the family Asteraceae contains steroids, reducing sugars, phenolic, flavonoids, saponins, tannins and triterpenoids. Therefore, this study is designed to investigate its antioxidant, analgesic and CNS depressant effects. Materials and Methods: The antioxidant activity of methanolic extract of S. nodiflora (SN) was determined using Folin Ciocalteu reagent, phosphomolybdenum method, free radical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and the reducing power activity. Analgesic activity was done by acetic acid and formalin model and CNS depressant activity was measured by the hole cross and open field method. Results: The total phenols and total antioxidant capacity of SN was found to be 37.38 < 2.01 mg/g equivalent of gallic acid and 433.37 < 4.22 mg/gm equivalent of ascorbic acid. The percentage (%) scavenging of DPPH free radical was found to be concentration dependent and IC50 value was 125.89 < 2.23 µg/ml while the IC50 value of standard ascorbic acid was found to be 16.76 < 0.11 µg/ml. The reducing power of SN was found to be concentration dependent. Acetic acid and formalin models are peripherally acting analgesic methods. The oral administration of both doses (100 and 200 mg/kg b.wt.) of SN significantly (p<0.001) inhibited 40.06% and 61.83% writhing response induced by acetic acid whereas oral administration of the same doses of SN significantly (p<0.001) inhibited 56.96% and 62.60% itching response induced by formalin. The methanolic extract of SN, at the dose of 250 mg/kg and 500 mg/kg b.wt. produced significant (P<0.001) decrease of locomotion. This is the first report of CNS depressant activity of the plant. Published 2016-11-28T09:10:57Z 2016-11-28T09:10:57Z 2016-10 Article Nahar, L., Zahan, R., Morshed, M. T. I., Haque, A., Alam, Z., & Mosaddik, A. (2012). Antioxidant, analgesic and CNS depressant effects of synedrella nodiflora. Pharmacognosy Journal, 4(31), 29-36. doi:10.5530/pj.2012.31.6 09753575 http://hdl.handle.net/10361/7011 en https://goo.gl/fMRYb9 © 2012 Elsevier Ltd. |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
Synedrella nodiflora Antioxidant Free radical Analgesic activity CNS depressant |
| spellingShingle |
Synedrella nodiflora Antioxidant Free radical Analgesic activity CNS depressant Nahar, Laizuman, Zahan, Ronok Ibn Morshed, Mahmud Tareq Haque, Anamul Alam, Zahangir Mosaddik, Ashik Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| description |
This article was published in Pharmacognosy Journal [© 2012 Elsevier Ltd.] and the definite version is available at http://www.sciencedirect.com/science/article/pii/S0975357512800824 The article website is at: http://www.sciencedirect.com/science/journal/09753575/4 |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Nahar, Laizuman, Zahan, Ronok Ibn Morshed, Mahmud Tareq Haque, Anamul Alam, Zahangir Mosaddik, Ashik |
| format |
Article |
| author |
Nahar, Laizuman, Zahan, Ronok Ibn Morshed, Mahmud Tareq Haque, Anamul Alam, Zahangir Mosaddik, Ashik |
| author_sort |
Nahar, Laizuman, |
| title |
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| title_short |
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| title_full |
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| title_fullStr |
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| title_full_unstemmed |
Antioxidant, analgesic and CNS depressant effects of Synedrella nodiflora |
| title_sort |
antioxidant, analgesic and cns depressant effects of synedrella nodiflora |
| publisher |
© 2012 Elsevier Ltd. |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7011 |
| work_keys_str_mv |
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1814308789882454016 |