Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson
This article was published in Turkish Journal of Pharmaceutical Sciences [© 2013 Turkish Journal of Pharmaceutical Sciences] and the definite version is available at: http://journal.teb.org.tr/1032013(3)%20405-414.pdf The article website is at: http://journal.eczakademi.org
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© 2013 Turkish Journal of Pharmaceutical Sciences
2016
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| Acesso em linha: | http://hdl.handle.net/10361/6926 |
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10361-69262016-11-23T07:16:28Z Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson Zahan, Ronok Kabir, Seiina Mosaddik, Ashik Chowdhury, Abdullah Mohammad Sarwaruddin Hasan, Choudhury Mahmood Rashid, Mohammad Abdur Department of Pharmacy, BRAC University Antioxidants Antineoplastic agents Annonaceae Ethyl acetate Body weight Mice as laboratory animals This article was published in Turkish Journal of Pharmaceutical Sciences [© 2013 Turkish Journal of Pharmaceutical Sciences] and the definite version is available at: http://journal.teb.org.tr/1032013(3)%20405-414.pdf The article website is at: http://journal.eczakademi.org The present study has been designed to investigate the antioxidant and antitumor activities of ethyl acetate (EA) extract of stem bark of Polyalthia simiarum (Annonaceae). Antioxidant potential of the EA extract was evaluated in vitro by DPPH (1,l-diphenyl-2-picrylhydrazyl) scavenging assay method. The EA extract showed free radical scavenging activity with IC50 value of 24.08 ± 0.30 fig/mL. The antitumor activity of the extract was determined against Ehrlich ascites carcinoma (EAC) in mice at 25 mg/kg and 5Í) mg/kg body weight intraperitoneal. Significant (p<0.001) increase of survival time by 25 ± 0.57 and 27 ± 0.40 days by the EA extract treated tumor bearing mice was confirmed with respect to the control group (22 ± 0.12 days). Hematological studies revealed that the hemoglobin (Hb) content was decreased in EAC treated mice whereas restoration to close to normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC and increase in WBC counts in extract treated animals when compared to EAC affected animals. Therefore, the EA extract of P. simiarum was capable to exhibit moderate antioxidant and antitumor activities. This is the first report of antioxidant and antitumor potential of P. simiarum. Published 2016-11-23T05:55:29Z 2016-11-23T05:55:29Z 2013 Article Kabir, S., Zahan, R., Mosaddik, A., Chowdhury, A. M. S., Hasan, C. M., & Rashid, M. A. (2013). Antioxidant and antitumor activities of polyalthia simiarum (buch.-ham. ex hook. F. & thomson) hook. F. & thomson. [Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson'un antioksidan ve antitümör aktivitesi] Turkish Journal of Pharmaceutical Sciences, 10(3), 405-413. 1304530X http://hdl.handle.net/10361/6926 en http://journal.teb.org.tr/1032013(3)%20405-414.pdf © 2013 Turkish Journal of Pharmaceutical Sciences |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antioxidants Antineoplastic agents Annonaceae Ethyl acetate Body weight Mice as laboratory animals |
| spellingShingle |
Antioxidants Antineoplastic agents Annonaceae Ethyl acetate Body weight Mice as laboratory animals Zahan, Ronok Kabir, Seiina Mosaddik, Ashik Chowdhury, Abdullah Mohammad Sarwaruddin Hasan, Choudhury Mahmood Rashid, Mohammad Abdur Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| description |
This article was published in Turkish Journal of Pharmaceutical Sciences [© 2013 Turkish Journal of Pharmaceutical Sciences] and the definite version is available at: http://journal.teb.org.tr/1032013(3)%20405-414.pdf The article website is at: http://journal.eczakademi.org |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Zahan, Ronok Kabir, Seiina Mosaddik, Ashik Chowdhury, Abdullah Mohammad Sarwaruddin Hasan, Choudhury Mahmood Rashid, Mohammad Abdur |
| format |
Article |
| author |
Zahan, Ronok Kabir, Seiina Mosaddik, Ashik Chowdhury, Abdullah Mohammad Sarwaruddin Hasan, Choudhury Mahmood Rashid, Mohammad Abdur |
| author_sort |
Zahan, Ronok |
| title |
Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| title_short |
Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| title_full |
Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| title_fullStr |
Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| title_full_unstemmed |
Antioxidant and antitumor activities of Polyalthia simiarum (Buch.-Ham. ex Hook. F. & Thomson) Hook. F. & Thomson |
| title_sort |
antioxidant and antitumor activities of polyalthia simiarum (buch.-ham. ex hook. f. & thomson) hook. f. & thomson |
| publisher |
© 2013 Turkish Journal of Pharmaceutical Sciences |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/6926 |
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