Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice

This article was published in Asian Pacific Journal of Reproduction [© 2014 Elsevier (Singapore) Pte Ltd] and the definite version is available at: http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db3...

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Autori principali:	Ripa, Farhana Alam, Khatun, Mst. Hajera, Nesa, Mst. Luthfun, Islam, Rafikul, Al mamum, Kadir, Shahin
Altri autori:	Department of Pharmacy, BRAC University
Natura:	Articolo
Lingua:	English
Pubblicazione:	© 2014 Elsevier (Singapore) Pte Ltd 2016
Soggetti:	Phyllanthus reticulatus Methanolic extract Hypoglycemic activity OGTT Phytochemical Antidiarrheal Castor oil Magnesium sulfate
Accesso online:	http://hdl.handle.net/10361/6887

id	10361-6887
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spelling	10361-68872016-11-21T09:45:51Z Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice Ripa, Farhana Alam Khatun, Mst. Hajera Nesa, Mst. Luthfun Islam, Rafikul Al mamum Kadir, Shahin Department of Pharmacy, BRAC University Phyllanthus reticulatus Methanolic extract Hypoglycemic activity OGTT Phytochemical Antidiarrheal Castor oil Magnesium sulfate This article was published in Asian Pacific Journal of Reproduction [© 2014 Elsevier (Singapore) Pte Ltd] and the definite version is available at: http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82 The article website is at: http://www.sciencedirect.com/science/journal/23050500 Objective To assess the anti-diabetic and antidiarrheal activity of methanolic extract of Phyllanthus reticulates (P. reticulates) leaves in an animal model. Methods Phytochemical screening of methanolic extract of P. reticulatus leaves has been performed. Antidiabetic activity have been done by OGTT, normoglycemic hyperglycemia and alloxan induced diabetic mice. Plant extracts (150 mg/kg and 300 mg/kg, b.w.) were administered orally in fasting glucose loaded mice with regard to normal control and in alloxan induced (110 mg/kg body weight i.p.) diabetic mice in comparison with reference drug Metformin hydrochloride (100 mg/kg) during 7 day test period. Antidiarrheal test was conducted by castor oil and magnesium sulfate. Results Findings confirmed that the continuous post-treatment for 7 days with both extracts showed significant (P < 0.05) hypoglycemic activity in OGTT, normoglycemic and alloxan induced mouse models. Castor oil and Magnesium sulfate induced diarrheal test of the extract (200 and 400 mg/kg) has given significant effect in compairing to control diarrheal group. Conclusion Methanolic extract of P. reticulatus leaves have shown significant antidiabetic and antidiarrheal properties. Published 2016-11-21T08:27:44Z 2016-11-21T08:27:44Z 2014-06 Article Khatun, H., Nesa, L., Islam, R., Ripa, F. A., Mamum, A., & Kadir, S. (2014). Antidiabetic and antidiarrheal effects of the methanolic extract of phyllanthus reticulatus leaves in mice. Asian Pacific Journal of Reproduction, 3(2), 121-127. doi:10.1016/S2305-0500(14)60015-4 23050500 http://hdl.handle.net/10361/6887 en http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82 © 2014 Elsevier (Singapore) Pte Ltd
institution	Brac University
collection	Institutional Repository
language	English
topic	Phyllanthus reticulatus Methanolic extract Hypoglycemic activity OGTT Phytochemical Antidiarrheal Castor oil Magnesium sulfate
spellingShingle	Phyllanthus reticulatus Methanolic extract Hypoglycemic activity OGTT Phytochemical Antidiarrheal Castor oil Magnesium sulfate Ripa, Farhana Alam Khatun, Mst. Hajera Nesa, Mst. Luthfun Islam, Rafikul Al mamum Kadir, Shahin Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
description	This article was published in Asian Pacific Journal of Reproduction [© 2014 Elsevier (Singapore) Pte Ltd] and the definite version is available at: http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82 The article website is at: http://www.sciencedirect.com/science/journal/23050500
author2	Department of Pharmacy, BRAC University
author_facet	Department of Pharmacy, BRAC University Ripa, Farhana Alam Khatun, Mst. Hajera Nesa, Mst. Luthfun Islam, Rafikul Al mamum Kadir, Shahin
format	Article
author	Ripa, Farhana Alam Khatun, Mst. Hajera Nesa, Mst. Luthfun Islam, Rafikul Al mamum Kadir, Shahin
author_sort	Ripa, Farhana Alam
title	Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
title_short	Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
title_full	Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
title_fullStr	Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
title_full_unstemmed	Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
title_sort	antidiabetic and antidiarrheal effects of the methanolic extract of phyllanthus reticulatus leaves in mice
publisher	© 2014 Elsevier (Singapore) Pte Ltd
publishDate	2016
url	http://hdl.handle.net/10361/6887
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Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice

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