Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity
This article was published in Pharmacognosy Research [© 2014 Pharmacognosy Network Worldwide] and the definite version is available at: http: http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=2;spage=180;epage=187;aulast=Nahar The article website is at: http://www.phcogres....
| 主要な著者: | , , , , , |
|---|---|
| その他の著者: | |
| フォーマット: | 論文 |
| 出版事項: |
© 2014 Pharmacognosy Network Worldwide
2016
|
| 主題: | |
| オンライン･アクセス: | http://hdl.handle.net/10361/6825 |
| id |
10361-6825 |
|---|---|
| record_format |
dspace |
| spelling |
10361-68252016-12-04T08:25:40Z Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity Nahar, Laizuman Haque, Ekramul Nasrin, Fatema Mosaddik, Ashik Zahan, Ronok Haque, Anamul Department of Pharmacy, BRAC University Alloxan Antioxidant activity Diphenyl-2-picrylhydrazyl Hyperglycemia Metformin Hydrochloride Oxidative stress This article was published in Pharmacognosy Research [© 2014 Pharmacognosy Network Worldwide] and the definite version is available at: http: http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=2;spage=180;epage=187;aulast=Nahar The article website is at: http://www.phcogres.com Oxidative stress not only develops complications in diabetic (type 1 and type 2) but also contributes to beta cell destruction in type 2 diabetes in insulin resistance hyperglycemia. Glucose control plays an important role in the pro-oxidant/antioxidant balance. Some antidiabetic agents may by themselves have antioxidant properties independently of their role on glucose control. Objective: The present investigation draws a comparison of the protective antioxidant activity, total phenol content and the antihyperglycemic activity of the methanolic extract of Cajanus cajan root (MCC) and Tamarindus indica seeds (MTI). Materials and Methods: Antidiabetic potentials of the plant extracts were evaluated in alloxan-induced diabetic Swiss albino mice. The plant extracts at the doses of 200 and 400 mg/kg body weight was orally administered for glucose tolerance test during 1-hour study and hypoglycemic effect during 5-day study period in comparison with reference drug Metformin HCl (50 mg/kg). In vitro antioxidant potential of MCC and MTI was investigated by using 1, 1- diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity at 517 nm. Total phenolic content, total antioxidant capacity and reducing power activity was also assayed. Results: There was a significant decrease in fasting serum glucose level (P < 0.001), reduction in blood glucose level (P < 0.001) in 5-days study, observed in the alloxan-induced diabetic mice. The reduction efficacy of blood glucose level of both the extracts is proportional to their dose but MCC is more potent than MTI. Antioxidant study and quantification of phenolic compound of both the extracts revealed that they have high antioxidant capacity. Conclusion: These studies showed that MCC and MTI have both hypoglycemic and antioxidant potential but MCC is more potent than MTI. The present study suggests that both MCC and MTI could be used in managing oxidative stress. Published 2016-11-14T10:05:11Z 2016-11-14T10:05:11Z 2014 Article Nahar, L., Nasrin, F., Zahan, R., Haque, A., Haque, E., & Mosaddik, A. (2014). Comparative study of antidiabetic activity of cajanus cajan and tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity. Pharmacognosy Research, 6(2), 180-187. doi:10.4103/0974-8490.129043 http://hdl.handle.net/10361/6825 10.4103/0974-8490.129043 https://goo.gl/7H41vC © 2014 Pharmacognosy Network Worldwide |
| institution |
Brac University |
| collection |
Institutional Repository |
| topic |
Alloxan Antioxidant activity Diphenyl-2-picrylhydrazyl Hyperglycemia Metformin Hydrochloride Oxidative stress |
| spellingShingle |
Alloxan Antioxidant activity Diphenyl-2-picrylhydrazyl Hyperglycemia Metformin Hydrochloride Oxidative stress Nahar, Laizuman Haque, Ekramul Nasrin, Fatema Mosaddik, Ashik Zahan, Ronok Haque, Anamul Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| description |
This article was published in Pharmacognosy Research [© 2014 Pharmacognosy Network Worldwide] and the definite version is available at: http: http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=2;spage=180;epage=187;aulast=Nahar The article website is at: http://www.phcogres.com |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Nahar, Laizuman Haque, Ekramul Nasrin, Fatema Mosaddik, Ashik Zahan, Ronok Haque, Anamul |
| format |
Article |
| author |
Nahar, Laizuman Haque, Ekramul Nasrin, Fatema Mosaddik, Ashik Zahan, Ronok Haque, Anamul |
| author_sort |
Nahar, Laizuman |
| title |
Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| title_short |
Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| title_full |
Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| title_fullStr |
Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| title_full_unstemmed |
Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| title_sort |
comparative study of antidiabetic activity of cajanus cajan and tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity |
| publisher |
© 2014 Pharmacognosy Network Worldwide |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/6825 |
| work_keys_str_mv |
AT naharlaizuman comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity AT haqueekramul comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity AT nasrinfatema comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity AT mosaddikashik comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity AT zahanronok comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity AT haqueanamul comparativestudyofantidiabeticactivityofcajanuscajanandtamarindusindicainalloxaninduceddiabeticmicewithareferencetoinvitroantioxidantactivity |
| _version_ |
1814307242271309824 |