Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats

This article was published in Tropical Journal of Pharmaceutical Research [© 2014 Tropical Journal of Pharmaceutical Research] and the definite version is available at: http://www.ajol.info/index.php/tjpr/article/view/101488/90672

Bibliographic Details
Main Authors:	Ripa, Farhana Alam, Ibn Morshed, Mahmud Tareq, Afsana-Al-Sharmin, Papon, Shahed Bulbul, Islam, Md Rafiqul, Sheikh, Zara
Other Authors:	Department of Pharmacy, BRAC University
Format:	Article
Published:	© 2014 Tropical Journal of Pharmaceutical Research 2016
Subjects:	Dimocarpus longan lour CNS depressant Analgesic Anti-diarrheal
Online Access:	http://hdl.handle.net/10361/6822 http://dx.doi.org/10.4314/tjpr.v13i2.11

id	10361-6822
record_format	dspace
spelling	10361-68222016-12-04T11:04:40Z Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats Ripa, Farhana Alam Ibn Morshed, Mahmud Tareq Afsana-Al-Sharmin Papon, Shahed Bulbul Islam, Md Rafiqul Sheikh, Zara Department of Pharmacy, BRAC University Dimocarpus longan lour CNS depressant Analgesic Anti-diarrheal This article was published in Tropical Journal of Pharmaceutical Research [© 2014 Tropical Journal of Pharmaceutical Research] and the definite version is available at: http://www.ajol.info/index.php/tjpr/article/view/101488/90672 Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents. Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively. Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model. Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model. Published 2016-11-14T10:04:57Z 2016-11-14T10:04:57Z 2014 Article Ripa, F. A., Ibn Morshed, M. T., Afsana-Al-Sharmin, Papon, S. B., Islam, M. R., & ZaraSheikh. (2014). Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of dimocarpus longan lour in rats.Tropical Journal of Pharmaceutical Research,13(2), 235-242. doi:10.4314/tjpr.v13i2.11 1596-9827 http://hdl.handle.net/10361/6822 http://dx.doi.org/10.4314/tjpr.v13i2.11 http://www.ajol.info/index.php/tjpr/article/view/101488 © 2014 Tropical Journal of Pharmaceutical Research
institution	Brac University
collection	Institutional Repository
topic	Dimocarpus longan lour CNS depressant Analgesic Anti-diarrheal
spellingShingle	Dimocarpus longan lour CNS depressant Analgesic Anti-diarrheal Ripa, Farhana Alam Ibn Morshed, Mahmud Tareq Afsana-Al-Sharmin Papon, Shahed Bulbul Islam, Md Rafiqul Sheikh, Zara Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
description	This article was published in Tropical Journal of Pharmaceutical Research [© 2014 Tropical Journal of Pharmaceutical Research] and the definite version is available at: http://www.ajol.info/index.php/tjpr/article/view/101488/90672
author2	Department of Pharmacy, BRAC University
author_facet	Department of Pharmacy, BRAC University Ripa, Farhana Alam Ibn Morshed, Mahmud Tareq Afsana-Al-Sharmin Papon, Shahed Bulbul Islam, Md Rafiqul Sheikh, Zara
format	Article
author	Ripa, Farhana Alam Ibn Morshed, Mahmud Tareq Afsana-Al-Sharmin Papon, Shahed Bulbul Islam, Md Rafiqul Sheikh, Zara
author_sort	Ripa, Farhana Alam
title	Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
title_short	Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
title_full	Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
title_fullStr	Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
title_full_unstemmed	Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
title_sort	central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of dimocarpus longan lour in rats
publisher	© 2014 Tropical Journal of Pharmaceutical Research
publishDate	2016
url	http://hdl.handle.net/10361/6822 http://dx.doi.org/10.4314/tjpr.v13i2.11
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Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats

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