Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model

Synthetic compounds are encompassing the major ther apeutic classes of drugs which resemblance to the n atural or existing therapeutically active compounds. Herewith four synthetic compounds i.e. 2-bromopropylamine hydrobromide, 3-bromopropyl ammonium bromide, ortho -a...

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Hlavní autoři:	Md. Hamiduzzaman, Dey, Avijit, Mannan, Sultana Juhara, Rahman, S. M. Abdur
Další autoři:	Department of Pharmacy, BRAC University
Médium:	Článek
Vydáno:	© 2014 Der Pharmacia Lettre 2016
Témata:	Analgesic activity Antipyretic activity CNS depressant activity Hypoglycemic activity Synthetic compounds
On-line přístup:	http://hdl.handle.net/10361/6821

id	10361-6821
record_format	dspace
spelling	10361-68212016-12-22T11:05:24Z Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model Md. Hamiduzzaman Dey, Avijit Mannan, Sultana Juhara Rahman, S. M. Abdur Department of Pharmacy, BRAC University Analgesic activity Antipyretic activity CNS depressant activity Hypoglycemic activity Synthetic compounds Synthetic compounds are encompassing the major ther apeutic classes of drugs which resemblance to the n atural or existing therapeutically active compounds. Herewith four synthetic compounds i.e. 2-bromopropylamine hydrobromide, 3-bromopropyl ammonium bromide, ortho -amino aniline and benzimidazole-2-thiol were subje cted for analgesic, antipyretic, hypoglycemic and CNS de pressant activity in mice and rat model following s tandard protocol. Among the four supplied synthetic compoun ds, benzimidazole-2-thiol and 3-bromopropyl ammoniu m bromide at a dose of 50 mg/kg body wt revealed sign ificant analgesic activity with 37.85% and 42.85% i nhibition of writhing (P value < 0.001 in both cases). None of t he test samples showed antipyretic activity in rat model at a dose of 50 mg/kg body wt in comparable with standard ant ipyretic drug Paracetamol. On the other hand benzim idazole- 2-thiol reduced blood glucose level with respect to standard drug Glibenclamide having P value 0.00082 and 3- bromopropyl ammonium bromide lengthened the Na-phen obarbitone induced sleeping time having the P value 0.0009 which was statistically significant. Published 2016-11-14T10:04:52Z 2016-11-14T10:04:52Z 2014 Article Hamiduzzaman, M., Mannan, S. J., Dey, A., & Abdur Rahman, S. M. (2014). Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model. Der Pharmacia Lettre, 6(1), 47-53. 09755071 http://hdl.handle.net/10361/6821 http://scholarsresearchlibrary.com/dpl-vol6-iss1/DPL-2014-6-1-47-53.pdf © 2014 Der Pharmacia Lettre
institution	Brac University
collection	Institutional Repository
topic	Analgesic activity Antipyretic activity CNS depressant activity Hypoglycemic activity Synthetic compounds
spellingShingle	Analgesic activity Antipyretic activity CNS depressant activity Hypoglycemic activity Synthetic compounds Md. Hamiduzzaman Dey, Avijit Mannan, Sultana Juhara Rahman, S. M. Abdur Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
description	Synthetic compounds are encompassing the major ther apeutic classes of drugs which resemblance to the n atural or existing therapeutically active compounds. Herewith four synthetic compounds i.e. 2-bromopropylamine hydrobromide, 3-bromopropyl ammonium bromide, ortho -amino aniline and benzimidazole-2-thiol were subje cted for analgesic, antipyretic, hypoglycemic and CNS de pressant activity in mice and rat model following s tandard protocol. Among the four supplied synthetic compoun ds, benzimidazole-2-thiol and 3-bromopropyl ammoniu m bromide at a dose of 50 mg/kg body wt revealed sign ificant analgesic activity with 37.85% and 42.85% i nhibition of writhing (P value < 0.001 in both cases). None of t he test samples showed antipyretic activity in rat model at a dose of 50 mg/kg body wt in comparable with standard ant ipyretic drug Paracetamol. On the other hand benzim idazole- 2-thiol reduced blood glucose level with respect to standard drug Glibenclamide having P value 0.00082 and 3- bromopropyl ammonium bromide lengthened the Na-phen obarbitone induced sleeping time having the P value 0.0009 which was statistically significant.
author2	Department of Pharmacy, BRAC University
author_facet	Department of Pharmacy, BRAC University Md. Hamiduzzaman Dey, Avijit Mannan, Sultana Juhara Rahman, S. M. Abdur
format	Article
author	Md. Hamiduzzaman Dey, Avijit Mannan, Sultana Juhara Rahman, S. M. Abdur
author_sort	Md. Hamiduzzaman
title	Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
title_short	Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
title_full	Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
title_fullStr	Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
title_full_unstemmed	Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
title_sort	evaluation of analgesic, antipyretic, hypoglycemic and cns depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model
publisher	© 2014 Der Pharmacia Lettre
publishDate	2016
url	http://hdl.handle.net/10361/6821
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Evaluation of analgesic, antipyretic, hypoglycemic and CNS depressant activity of 2-bromopopylamine hydrobromide, 3-bromopopyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol in animal model

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