| Resumo: | Synthetic compounds are encompassing the major ther
apeutic classes of drugs which resemblance to the n
atural or
existing therapeutically active compounds. Herewith
four synthetic compounds i.e. 2-bromopropylamine
hydrobromide, 3-bromopropyl ammonium bromide, ortho
-amino aniline and benzimidazole-2-thiol were subje
cted
for analgesic, antipyretic, hypoglycemic and CNS de
pressant activity in mice and rat model following s
tandard
protocol. Among the four supplied synthetic compoun
ds, benzimidazole-2-thiol and 3-bromopropyl ammoniu
m
bromide at a dose of 50 mg/kg body wt revealed sign
ificant analgesic activity with 37.85% and 42.85% i
nhibition of
writhing (P value < 0.001 in both cases). None of t
he test samples showed antipyretic activity in rat
model at a dose
of 50 mg/kg body wt in comparable with standard ant
ipyretic drug Paracetamol. On the other hand benzim
idazole-
2-thiol reduced blood glucose level with respect to
standard drug Glibenclamide having P value 0.00082
and 3-
bromopropyl ammonium bromide lengthened the Na-phen
obarbitone induced sleeping time having the P value
0.0009 which was statistically significant.
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