A pragmatic approach to the analysis of a combination formulation

Detalles Bibliográficos
Autores principales:	Mubtasim, Noshin, Kabir, Eva Rahman, Podder, Ashis Kumar, Bhadra, Subrata
Otros Autores:	Department of Pharmacy, BRAC University
Formato:	Artículo
Publicado:	© 2016 Elsevier B.V. 2016
Materias:	Rosuvastatin calcium Amlodipine besylate Compatible Combination formulation Method validation
Acceso en línea:	http://hdl.handle.net/10361/6813

id	10361-6813
record_format	dspace
spelling	10361-68132019-08-05T08:12:44Z A pragmatic approach to the analysis of a combination formulation Mubtasim, Noshin Kabir, Eva Rahman Podder, Ashis Kumar Bhadra, Subrata Department of Pharmacy, BRAC University Rosuvastatin calcium Amlodipine besylate Compatible Combination formulation Method validation This article was published in the Saudi Pharmaceutical Journal [© 2016 Elsevier B.V.] and the definite version is available at: http://www.sciencedirect.com/science/article/pii/S1319016415001152 The aim of the paper was to formulate a combined oral dosage form of rosuvastatin calcium and amlodipine besylate and to develop and validate an analytical method to be adopted for both routine quality control assay and in vitro dissolution studies of the formulation. The proposed combination formulation has shown compatibility with the chosen excipients, verified through FT-IR study. A novel gradient RP-HPLC method was developed and validated according to the ICH guideline which was found to be suitable for the simultaneous estimation of rosuvastatin calcium and amlodipine besylate from the formulation. The retention time of 2.7 and 6.08 min allows the analysis of large amount of samples with less mobile phase which makes the method economic. The dissolution profiles of both the drugs in different dissolution medium were encouraging which makes the combination formulation of rosuvastatin calcium and amlodipine besylate superior and effective in achieving patient compliance. 2016-11-14T10:04:14Z 2016-11-14T10:04:14Z 2016 Article Mubtasim, N., Kabir, E. R., Podder, A. K., & Bhadra, S. (2016). A pragmatic approach to the analysis of a combination formulation. Saudi Pharmaceutical Journal, 24(6), 689 697. doi:10.1016/j.jsps.2015.06.004 13190164 http://hdl.handle.net/10361/6813 10.1016/j.jsps.2015.06.004 http://www.sciencedirect.com/science/article/pii/S1319016415001152 © 2016 Elsevier B.V.
institution	Brac University
collection	Institutional Repository
topic	Rosuvastatin calcium Amlodipine besylate Compatible Combination formulation Method validation
spellingShingle	Rosuvastatin calcium Amlodipine besylate Compatible Combination formulation Method validation Mubtasim, Noshin Kabir, Eva Rahman Podder, Ashis Kumar Bhadra, Subrata A pragmatic approach to the analysis of a combination formulation
description	This article was published in the Saudi Pharmaceutical Journal [© 2016 Elsevier B.V.] and the definite version is available at: http://www.sciencedirect.com/science/article/pii/S1319016415001152
author2	Department of Pharmacy, BRAC University
author_facet	Department of Pharmacy, BRAC University Mubtasim, Noshin Kabir, Eva Rahman Podder, Ashis Kumar Bhadra, Subrata
format	Article
author	Mubtasim, Noshin Kabir, Eva Rahman Podder, Ashis Kumar Bhadra, Subrata
author_sort	Mubtasim, Noshin
title	A pragmatic approach to the analysis of a combination formulation
title_short	A pragmatic approach to the analysis of a combination formulation
title_full	A pragmatic approach to the analysis of a combination formulation
title_fullStr	A pragmatic approach to the analysis of a combination formulation
title_full_unstemmed	A pragmatic approach to the analysis of a combination formulation
title_sort	pragmatic approach to the analysis of a combination formulation
publisher	© 2016 Elsevier B.V.
publishDate	2016
url	http://hdl.handle.net/10361/6813
work_keys_str_mv	AT mubtasimnoshin apragmaticapproachtotheanalysisofacombinationformulation AT kabirevarahman apragmaticapproachtotheanalysisofacombinationformulation AT podderashiskumar apragmaticapproachtotheanalysisofacombinationformulation AT bhadrasubrata apragmaticapproachtotheanalysisofacombinationformulation AT mubtasimnoshin pragmaticapproachtotheanalysisofacombinationformulation AT kabirevarahman pragmaticapproachtotheanalysisofacombinationformulation AT podderashiskumar pragmaticapproachtotheanalysisofacombinationformulation AT bhadrasubrata pragmaticapproachtotheanalysisofacombinationformulation
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A pragmatic approach to the analysis of a combination formulation

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