A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle
This article was published in Natural Product Research [© 2016 Taylor and Francis Ltd.] and the definite version is available at: https://goo.gl/ba4EOj
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© 2016 Taylor and Francis Ltd.
2016
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10361-67972016-12-04T10:55:02Z A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle Akter, Raushanara A. Uddin, Shaikh J. Tiralongo, Joe Grice, Darren Tiralongo, Evelin Department of Pharmacy, BRAC University Blumea lacera leaves Cell cycle analysis Cytotoxicity Diterpenoid glycoside Flavonoid glycoside This article was published in Natural Product Research [© 2016 Taylor and Francis Ltd.] and the definite version is available at: https://goo.gl/ba4EOj A new diterpenoid glycoside, 6E,10E,14Z-(3S)-17-hydroxygeranyllinalool-17-O-β-d-glucopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside (1) together with the known diterpenoid glycoside (2) and two known flavonoid glycosides (3, 4) were isolated from the methanol extract of Blumea lacera leaves. The structures were determined by the interpretation of their spectroscopic data and comparison with the literature. All compounds were isolated for the first time from B. lacera and evaluated for their cytotoxic activity. Only the new compound (1) showed strong cytotoxic activity with the lowest IC50 value (8.3 μM) being displayed against MCF-7 breast cancer cells. In apoptosis and cell cycle analysis, 1 revealed strong apoptotic activity against MCF-7 cells (45.5% AV+/PI−) after 24 h, but showed no arresting of any of the cell cycle phases in MCF-7. © 2016 Informa UK Limited, trading as Taylor & Francis Group. Published 2016-11-09T07:07:06Z 2016-11-09T07:07:06Z 2016 Article Akter, R., Uddin, S. J., Tiralongo, J., Grice, I. D., & Tiralongo, E. (2016). A new cytotoxic diterpenoid glycoside from the leaves of blumea lacera and its effects on apoptosis and cell cycle. Natural Product Research, 30(23), 2688-2693. doi:10.1080/14786419.2016.1146887 14786419 http://hdl.handle.net/10361/6797 10.1080/14786419.2016.1146887 https://goo.gl/ba4EOj © 2016 Taylor and Francis Ltd. |
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Brac University |
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Institutional Repository |
| topic |
Blumea lacera leaves Cell cycle analysis Cytotoxicity Diterpenoid glycoside Flavonoid glycoside |
| spellingShingle |
Blumea lacera leaves Cell cycle analysis Cytotoxicity Diterpenoid glycoside Flavonoid glycoside Akter, Raushanara A. Uddin, Shaikh J. Tiralongo, Joe Grice, Darren Tiralongo, Evelin A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| description |
This article was published in Natural Product Research [© 2016 Taylor and Francis Ltd.] and the definite version is available at: https://goo.gl/ba4EOj |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Akter, Raushanara A. Uddin, Shaikh J. Tiralongo, Joe Grice, Darren Tiralongo, Evelin |
| format |
Article |
| author |
Akter, Raushanara A. Uddin, Shaikh J. Tiralongo, Joe Grice, Darren Tiralongo, Evelin |
| author_sort |
Akter, Raushanara A. |
| title |
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| title_short |
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| title_full |
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| title_fullStr |
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| title_full_unstemmed |
A new cytotoxic diterpenoid glycoside from the leaves of Blumea lacera and its effects on apoptosis and cell cycle |
| title_sort |
new cytotoxic diterpenoid glycoside from the leaves of blumea lacera and its effects on apoptosis and cell cycle |
| publisher |
© 2016 Taylor and Francis Ltd. |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/6797 |
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