Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population
This article was published in Breast Cancer [© 2016 The Japanese Breast Cancer Society] and the definite version is available at: http://link.springer.com/article/10.1007/s12282-016-0692-5
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© 2016 The Japanese Breast Cancer Society
2016
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10361/6796 |
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10361-6796 |
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10361-67962018-07-31T06:30:58Z Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population Parvin, Salma Islam, Md. Siddiqul Al-Mamun, Mir Md. Abdullah Islam, Mohammad Safiqul Ahmed, Maizbha Uddin Kabir, Eva Rahman Hasnat, Abul Department of Pharmacy, BRAC University BRCA1 BRCA2 Breast cancer HER2 RAD51 This article was published in Breast Cancer [© 2016 The Japanese Breast Cancer Society] and the definite version is available at: http://link.springer.com/article/10.1007/s12282-016-0692-5 Purpose: Breast cancer is considered as the most frequent female malignancy. Altered gene expressions due to genetic polymorphisms in the BRCA1, BRCA2, RAD51, and HER2 contribute toward the development of breast cancer, and yet, no such type of study has been conducted in the Bangladeshi population. This study was designed to evaluate the role of BRCA1rs80357713, BRCA1rs80357906, BRCA2rs11571653, RAD51rs1801320, and HER2rs1136201 polymorphisms as risk factors in the development of breast cancer in the Bangladeshi population. Methods: A total 310 patients with invasive breast cancers were recruited as cases from different public and private hospitals of Bangladesh, and 250 Bangladeshi healthy women matching age with the patients were recruited as controls. Polymerase chain reaction–restriction fragment length polymorphism method was used to analyze the genetic polymorphisms. Results: Patients carrying BRCA1/2 mutations, GC and GC plus CC genotypes of RAD51rs1801320, and AG plus GG genotype of HER2rs1136201 polymorphisms were found to be associated with breast cancer. In subgroup analysis, AG plus GG genotype of HER2rs1136201 was found to be associated with the breast cancer risk in the patients younger than 45 years of age compared with the older patients having more than 45 years of age, and RAD51rs1801320 was related to the tumor size and tumor aggressiveness (higher graded tumor). Conclusion: Our results indicate that BRCA1/BRCA2, RAD51rs1801320 and HER2rs1136201 polymorphisms were associated with breast cancer in the studied population. 2016-11-09T07:06:58Z 2016-11-09T07:06:58Z 2016 Article Parvin, S., Islam, M. S., Al-Mamun, M. M. A., Islam, M. S., Ahmed, M. U., Kabir, E. R., & Hasnat, A. (2016). Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the bangladeshi population. Breast Cancer, , 1-9. doi:10.1007/s12282-016-0692-5 13406868 http://hdl.handle.net/10361/6796 10.1007/s12282-016-0692-5 http://link.springer.com/article/10.1007/s12282-016-0692-5 © 2016 The Japanese Breast Cancer Society |
| institution |
Brac University |
| collection |
Institutional Repository |
| topic |
BRCA1 BRCA2 Breast cancer HER2 RAD51 |
| spellingShingle |
BRCA1 BRCA2 Breast cancer HER2 RAD51 Parvin, Salma Islam, Md. Siddiqul Al-Mamun, Mir Md. Abdullah Islam, Mohammad Safiqul Ahmed, Maizbha Uddin Kabir, Eva Rahman Hasnat, Abul Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| description |
This article was published in Breast Cancer [© 2016 The Japanese Breast Cancer Society] and the definite version is available at: http://link.springer.com/article/10.1007/s12282-016-0692-5 |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Parvin, Salma Islam, Md. Siddiqul Al-Mamun, Mir Md. Abdullah Islam, Mohammad Safiqul Ahmed, Maizbha Uddin Kabir, Eva Rahman Hasnat, Abul |
| format |
Article |
| author |
Parvin, Salma Islam, Md. Siddiqul Al-Mamun, Mir Md. Abdullah Islam, Mohammad Safiqul Ahmed, Maizbha Uddin Kabir, Eva Rahman Hasnat, Abul |
| author_sort |
Parvin, Salma |
| title |
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| title_short |
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| title_full |
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| title_fullStr |
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| title_full_unstemmed |
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population |
| title_sort |
association of brca1, brca2, rad51, and her2 gene polymorphisms with the breast cancer risk in the bangladeshi population |
| publisher |
© 2016 The Japanese Breast Cancer Society |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/6796 |
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