Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination
This project report is submitted in a partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016
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BRAC University
2016
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| Sarrera elektronikoa: | http://hdl.handle.net/10361/5302 |
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10361-5302 |
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10361-53022019-09-30T02:56:15Z Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination Khan, Tonima Akter Sharmin, Shahana Department of Pharmacy, BRAC University Pharmacy PEG6000 This project report is submitted in a partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016 Cataloged from PDF version of Internship report. Includes bibliographical references (page 54-55). The potential of solid dispersion based formulation using the combination of PEG6000 and croscarmellose sodium as drug carrier to enhance the dissolution performance and oral bioavailability of Fenofibrate, a poorly water soluble drug was investigated. Fenofibrate is a hydrophobic drug in fibrate class of drug which is mainly used in patients at risk of cardiovascular disease in the treatment of hypercholesterolemia and hypertriglyceridemia. Solid dispersions with different drug-to-carrier ratios were prepared by the physical mixture method and solvent method and characterized by dissolution testing within 30minutes. In vitro drug release were performed using US pharmacopeia type II apparatus (paddle-method) in 1000ml distilled water containing 0.75% w/v sodium lauryl sulfate at 75rpm for 30minutes. UV visible spectrophotometric method was selected for dissolution performance investigation at max 290 nm. In physical mixture method F5 (32.5%) and F11 (83%) and in solvent method F6 (39%) and F11 (38.5%) have showed good percentage of drug release. Tonima Akter Khan B. Pharmacy 2016-05-18T10:21:37Z 2016-05-18T10:21:37Z 2016 2016-02 Project report ID 12146039 http://hdl.handle.net/10361/5302 en BRAC University project report are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 55 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Pharmacy PEG6000 |
| spellingShingle |
Pharmacy PEG6000 Khan, Tonima Akter Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| description |
This project report is submitted in a partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2016 |
| author2 |
Sharmin, Shahana |
| author_facet |
Sharmin, Shahana Khan, Tonima Akter |
| format |
Project report |
| author |
Khan, Tonima Akter |
| author_sort |
Khan, Tonima Akter |
| title |
Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| title_short |
Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| title_full |
Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| title_fullStr |
Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| title_full_unstemmed |
Dissolution performance improvement of fenofibrate through secondary solid dispersion using PEG6000 and croscarmellose sodium combination |
| title_sort |
dissolution performance improvement of fenofibrate through secondary solid dispersion using peg6000 and croscarmellose sodium combination |
| publisher |
BRAC University |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/5302 |
| work_keys_str_mv |
AT khantonimaakter dissolutionperformanceimprovementoffenofibratethroughsecondarysoliddispersionusingpeg6000andcroscarmellosesodiumcombination |
| _version_ |
1814309328678551552 |