The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia
A Dissertation Submitted in Partial Fulfillment of the Requirements’ for the Degree of Master of Science in Biotechnology 2016.
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BRAC University
2016
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10361-50342019-09-30T03:31:19Z The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia Akther, Raisa Rahman, Dr. Hafizur Choudhury, Dr. Naiyyum Department of Mathematical and Natural Science, BRAC University Biotechnnology Mathematics & Natural Sciences Anaemia A Dissertation Submitted in Partial Fulfillment of the Requirements’ for the Degree of Master of Science in Biotechnology 2016. Cataloged from PDF version of thesis report. Includes bibliographical references (page 50-57). The most common causes of microcytosis are iron deficiency anemia (IDA) and Beta thalassemia trait (BTT). BTT is an important differential diagnosis of IDA in Southeast Asian countries including Bangladesh. A definitive diagnosis of BTT and IDA is based on the result of capillary electrophoresis and serum iron profiles. BTT often shows microcytosis, a normal or an increased red blood cell (RBC) count, and an elevated level of HbA2, which provide the basis for laboratory screening and diagnosis of IDA was made on the basis of decreased ferritin values. The purpose of this study was to explore the use of different red cell parameters with (RET – He) in diagnosis of BTT & IDA. A total of 210 samples were obtained from specimen reception unit of Icddr,b irrespective of sex. Complete blood count was performed to all individuals. Hemoglobin electrophoresis and serum ferritin was performed to samples with MCV less than 80 fl. Prevalence of BTT in this study was 16%, whereas IDA represented 16.6% of total 210 samples investigated. The lowest MCV values were seen in BTT compared with the IDA group. Red blood cell distribution width (RDW-CV) was the highest in IDA group followed by BTT group and then control group. Elevated RBCs count were seen in BTT than in IDA and normal group. A reduction in reticulocyte hemoglobin has been observed in other conditions besides iron deficiency, such as in thalassemia. Microcytosis accompanied by a high RBC count, normal RDW and an elevated level of HbA2 is suggestive of BTT. Microcytosis accompanied by a low ferritin value suggests iron deficiency. Besides measurement of the reticulocyte hemoglobin (RET-He) content is helpful in detecting early stages of iron deficiency prior to the development of anemia. Raisa Akther B. Biotechnology 2016-02-15T13:05:24Z 2016-02-15T13:05:24Z 2016 2016-01 Thesis ID 11276005 http://hdl.handle.net/10361/5034 en BRAC University thesis are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 57 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Biotechnnology Mathematics & Natural Sciences Anaemia |
| spellingShingle |
Biotechnnology Mathematics & Natural Sciences Anaemia Akther, Raisa The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| description |
A Dissertation Submitted in Partial Fulfillment of the Requirements’ for the Degree of Master of Science in Biotechnology 2016. |
| author2 |
Rahman, Dr. Hafizur |
| author_facet |
Rahman, Dr. Hafizur Akther, Raisa |
| format |
Thesis |
| author |
Akther, Raisa |
| author_sort |
Akther, Raisa |
| title |
The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| title_short |
The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| title_full |
The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| title_fullStr |
The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| title_full_unstemmed |
The value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| title_sort |
value of different red cell parameters in the diagnosis of microcytic hypochromic anaemia |
| publisher |
BRAC University |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/5034 |
| work_keys_str_mv |
AT aktherraisa thevalueofdifferentredcellparametersinthediagnosisofmicrocytichypochromicanaemia AT aktherraisa valueofdifferentredcellparametersinthediagnosisofmicrocytichypochromicanaemia |
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