Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome
This thesis report is submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Biotechnology, 2015.
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BRAC University
2016
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| Acceso en liña: | http://hdl.handle.net/10361/4879 |
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10361-48792019-09-30T04:12:30Z Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome Sinthi, Nudrat Ansari Choudhury, Naiyyum Ali, Liaquat Department of Mathematical and Natural Science, BRAC University Biotechnnology This thesis report is submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Biotechnology, 2015. Cataloged from PDF version of thesis report. Includes bibliographical references (page 46-58). Association of chronic arsenic exposure with diabetes mellitus is fairly well established, but the association of arsenic toxicity with glucose intolerance in pregnancy and with neonatal outcome have yet not been studied adequately. The present study was undertaken to explore the association of chronic arsenic exposure with gestational diabetes mellitus (GDM) and neonatal outcome in a Bangladeshi population. Under an observational cross-sectional design a total of 263 pregnant women (age in yrs, M±SD, 21±3.7) residing in an arsenic affected area of Bangladesh, were subjected to a 2 sample OGTT at third trimester of gestation. Clinical and anthropometric measurements were done by standard techniques. Degree of chronic arsenic exposure was assessed by the level of As in the usable (drinking, cooking, washing and bathing) water at the respective households and total urinary arsenic level. GDM was diagnosed by WHO criteria and neonatal outcome was assessed using APGAR Score measured by a Specialist Obstetrician. Serum glucose was measured by Glucose Oxidase method and As level in water (WAs) was measured by ultraviolet/visible spectrophotometry. Out of the 263 pregnant women 73(28%) developed GDM. WAs was significantly higher in the GDM as compared to the Non-GDM group [WAs, ìg/l, median (range), 62(34-354) vs 3.6(1.02-99), p<0.001]. Apger Score of the neonates from GDM mothers was significantly lower compared to the neonates from Non-GDM mothers [APGER Score, M±SD, 4.7±0.8 vs 6.4±0.7, p<0.001]. On Pearson’s correlation analysis in GDM subjects, both fasting and postprandial serum glucose levels were found to have a significant positive correlation with WAs levels (r=0.429;p=<0.001) and water arsenic and also significant positive correlation with water arsenic (r=0.234; p<0.001). The APGER Score of the neonates were found to have a significant negative correlation (r=- 0.233; p=0.041) with WAs level. Chronic arsenic exposure is associated with worsening of glucose intolerance during pregnancy and it also affects neonatal outcome in an adverse way. Nudrat Ansari Sinthi M. Biotechnology 2016-01-18T12:47:19Z 2016-01-18T12:47:19Z 2015 2015-12 Thesis ID 12176010 http://hdl.handle.net/10361/4879 en BRAC University thesis are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 81 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Biotechnnology |
| spellingShingle |
Biotechnnology Sinthi, Nudrat Ansari Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| description |
This thesis report is submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Biotechnology, 2015. |
| author2 |
Choudhury, Naiyyum |
| author_facet |
Choudhury, Naiyyum Sinthi, Nudrat Ansari |
| format |
Thesis |
| author |
Sinthi, Nudrat Ansari |
| author_sort |
Sinthi, Nudrat Ansari |
| title |
Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| title_short |
Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| title_full |
Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| title_fullStr |
Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| title_full_unstemmed |
Daily arsenic contamination associated with Gestational diabetes mellitus and neonatal outcome |
| title_sort |
daily arsenic contamination associated with gestational diabetes mellitus and neonatal outcome |
| publisher |
BRAC University |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/4879 |
| work_keys_str_mv |
AT sinthinudratansari dailyarseniccontaminationassociatedwithgestationaldiabetesmellitusandneonataloutcome |
| _version_ |
1814308432257220608 |