Study of acute toxicity of an unani medicine used in dysentery
This thesis report is submitted in partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2015.
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BRAC University
2015
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| Acceso en liña: | http://hdl.handle.net/10361/4439 |
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10361-44392019-09-30T04:22:24Z Study of acute toxicity of an unani medicine used in dysentery Raja, Abdul Al Hossain, Dr. M. Mahboob Department of Mathematical and Natural Science, BRAC University Biotechnology Department of mathematics and natural sciences Dysentery Unani Medicine This thesis report is submitted in partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2015. Cataloged from PDF version of thesis report. Includes bibliographical references (page 58-61). Marbelus is an Unani Medicine of unique combination of Bael (Aegle marmelos) fruit and Connessi (Holarrhena antidysenterica) bark, which is highly effective in diarrhoea, dysentery (Amoebic & Bacillary dysentery), giardiasis and helminthiasis. However, toxicity study of the Marbelus syrup is still lacking. The present study is to investigate the acute toxicity of Marbelus Syrup extract on Sprague Dawley rats at a dose of 2000 mg/kg body weight (BW). Sighting study was conducted in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg BW. No signs of toxicity and no deaths were observed. Based on the sighting study, we selected a dose of 2000 mg/kg BW and observed for 14 days. The study includes control and treatment group, each consisting of 5 female rats. The single oral dose of the Marbelus syrup did not produce mortality or significant changes in the body weight, food and water consumption. In the female rats there was significant (p=0.045) increase (16.40%) in total protein where albumin content was increased (1.56%) but not significantly (p=0.458) different from their corresponding control values. The decrease in urea content (0.80% decrease; p=0.691) & uric acid content was decreased by (12.54%; p=0.203) which was not statistically significant. The increase in both HDL cholesterol content (10.13% increase; p=0.46) & total cholesterol content (14.89% increase; p=0.23) was not statistically significant. It was observed that about 13.44% increase in triglyceride content of treated female rats in comparison to their control female rats which was statistically significant(p=0.030). However, total proteins were significantly increased indicating dehydration. Apart from triglyceride, other biochemistry parameters demonstrated no significant changes as compared to the control. M. Biotechnology 2015-09-23T06:22:16Z 2015-09-23T06:22:16Z 2015 2015-08 Thesis ID 11176003 http://hdl.handle.net/10361/4439 en 61 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Biotechnology Department of mathematics and natural sciences Dysentery Unani Medicine |
| spellingShingle |
Biotechnology Department of mathematics and natural sciences Dysentery Unani Medicine Raja, Abdul Al Study of acute toxicity of an unani medicine used in dysentery |
| description |
This thesis report is submitted in partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2015. |
| author2 |
Hossain, Dr. M. Mahboob |
| author_facet |
Hossain, Dr. M. Mahboob Raja, Abdul Al |
| format |
Thesis |
| author |
Raja, Abdul Al |
| author_sort |
Raja, Abdul Al |
| title |
Study of acute toxicity of an unani medicine used in dysentery |
| title_short |
Study of acute toxicity of an unani medicine used in dysentery |
| title_full |
Study of acute toxicity of an unani medicine used in dysentery |
| title_fullStr |
Study of acute toxicity of an unani medicine used in dysentery |
| title_full_unstemmed |
Study of acute toxicity of an unani medicine used in dysentery |
| title_sort |
study of acute toxicity of an unani medicine used in dysentery |
| publisher |
BRAC University |
| publishDate |
2015 |
| url |
http://hdl.handle.net/10361/4439 |
| work_keys_str_mv |
AT rajaabdulal studyofacutetoxicityofanunanimedicineusedindysentery |
| _version_ |
1814307841534590976 |