Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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Brac University
2024
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| Accesso online: | http://hdl.handle.net/10361/24396 |
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10361-243962024-10-24T21:03:13Z Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer Shobnam, Sohana Azam, Faruque School of Pharmacy, Brac University Phase II trials Breast cancer Efficacy endpoints Progression-free survival Breast Cancer. Breast Cancer--Survival. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from PDF version of thesis. Includes bibliographical references (pages 15-17). Metastatic breast cancer requires more investigation because of its high incidence. Efforts to improve the accessibility, evaluative simplicity, and predictive accuracy of clinical trial endpoints are ongoing. In this paper, we analyzed 410 Phase II clinical trials’ endpoints to assess the efficacy and impact of anticancer agents. We estimated the treatment effects for overall survival and progression-free survival using appropriate statistical methodologies. We found a significant moderate positive correlation between OS and PFS (r = 0.63, 95% CI 0.55–0.71, P < 0.001). Moreover, PFS predicted the OS with a 40% accuracy (R-sq= 0.40). Interestingly, PFS showed significant differences in 1-2-and-3-agent trials, however, this was not reflected in the OS for 2-and-3-agent trials, indicating the need for further validation of the surrogacy of PFS. Nonetheless, PFS is somewhat reliable surrogate of OS in phase II trials of breast cancer and we recommend finding a better surrogate than PFS. Sohana Shobnam B. Pharmacy 2024-10-24T05:01:32Z 2024-10-24T05:01:32Z ©2024 2024-05 Thesis ID 20146042 http://hdl.handle.net/10361/24396 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 17 pages application/pdf Brac University |
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Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Phase II trials Breast cancer Efficacy endpoints Progression-free survival Breast Cancer. Breast Cancer--Survival. |
| spellingShingle |
Phase II trials Breast cancer Efficacy endpoints Progression-free survival Breast Cancer. Breast Cancer--Survival. Shobnam, Sohana Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Azam, Faruque |
| author_facet |
Azam, Faruque Shobnam, Sohana |
| format |
Thesis |
| author |
Shobnam, Sohana |
| author_sort |
Shobnam, Sohana |
| title |
Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| title_short |
Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| title_full |
Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| title_fullStr |
Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| title_full_unstemmed |
Pooled analysis of progression-free survival and overall survival in phase II clinical trials of breast cancer |
| title_sort |
pooled analysis of progression-free survival and overall survival in phase ii clinical trials of breast cancer |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/24396 |
| work_keys_str_mv |
AT shobnamsohana pooledanalysisofprogressionfreesurvivalandoverallsurvivalinphaseiiclinicaltrialsofbreastcancer |
| _version_ |
1814308580025696256 |