A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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| Լեզու: | English |
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Brac University
2024
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| Առցանց հասանելիություն: | http://hdl.handle.net/10361/24298 |
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10361-242982024-10-03T21:05:09Z A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia Choki, Kinley Chowdhury, Namara Mariam Department of Pharmacy, Brac University Acute lymphoblastic leukemia Leukemia R/R B-cell precursor ALL FDA Blood cancer Lymphoblastic leukemia. Cancer--Immunotherapy. Monoclonal antibodies--Therapeutic use. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from PDF version of thesis. Includes bibliographical references (pages 35-36). Acute lymphoblastic Leukemia has currently about 6,550 new cases from which about 3,590 are male and about 2,960 are females. ALL occurs in fewer than half of 1% of all cancer in the US. There are multiple subtypes of ALL out of which there are two main types and only in some cases it can be cured. Treatment of different types are available for the acute lymphoblastic Leukemia (ALL). Some treatments are in the ongoing trials and some are standard treatments that are currently used. Blinatumomab is a bispecific monoclonal antibody approved by the US, FDA for the treatment in patients with relapsed or refractory B-cell precursor of ALL on the basis of phase 3 clinical trials that shows the efficacy and some manageable toxic effects. It shows superior overall survival as compared to standard chemotherapy. The refractory or relapsed acute lymphoblastic Leukemia (ALL) patients, when treated with the allogeneic stem cell transplantation and cytotoxic chemotherapy have poor prognosis or the pitiful rate of survival approximately 5%. In this review, the clinical trial data of blinatumomab is analysed, an evaluation of its effectiveness and safety in comparison to the chemotherapy is provided, which can be used to unfold the full potential of this drug in the future. Kinley Choki B. Pharmacy 2024-10-03T06:56:54Z 2024-10-03T06:56:54Z ©2024 2024-07 Thesis ID 20346072 http://hdl.handle.net/10361/24298 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 48 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Acute lymphoblastic leukemia Leukemia R/R B-cell precursor ALL FDA Blood cancer Lymphoblastic leukemia. Cancer--Immunotherapy. Monoclonal antibodies--Therapeutic use. |
| spellingShingle |
Acute lymphoblastic leukemia Leukemia R/R B-cell precursor ALL FDA Blood cancer Lymphoblastic leukemia. Cancer--Immunotherapy. Monoclonal antibodies--Therapeutic use. Choki, Kinley A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Chowdhury, Namara Mariam |
| author_facet |
Chowdhury, Namara Mariam Choki, Kinley |
| format |
Thesis |
| author |
Choki, Kinley |
| author_sort |
Choki, Kinley |
| title |
A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| title_short |
A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| title_full |
A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| title_fullStr |
A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| title_full_unstemmed |
A review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| title_sort |
review on bispecific antibody (blinatumomab) for the treatment of acute lymphoblastic leukemia |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/24298 |
| work_keys_str_mv |
AT chokikinley areviewonbispecificantibodyblinatumomabforthetreatmentofacutelymphoblasticleukemia AT chokikinley reviewonbispecificantibodyblinatumomabforthetreatmentofacutelymphoblasticleukemia |
| _version_ |
1814309390105182208 |