Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh
This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2024.
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Brac University
2024
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| Онлайн доступ: | http://hdl.handle.net/10361/24189 |
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10361-241892024-09-25T21:03:40Z Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh Shweta, Dipita Saha Haque, Fahim Kabir Monjurul Department of Mathematics and Natural Sciences, Brac University MRSA mecC Septicemia Methicillin resistant Staphylococcus aureus Inducible Clindamycin resistance Methicillin resistance. Staphylococcus aureus infections. This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2024. Cataloged from PDF version of thesis. Includes bibliographical references (pages 31-34). Upon being virtually resistant to all β lactam antibiotics, Methicillin Resistant Staphylococcus aureus (MRSA) infections are being commonly treated by clindamycin due to various benefits. But due to the inducible Macrolide Lincosamide Streptogramin B (MLSB) phenotype, clindamycin is no longer effective. The research aimed to explore different methods to find the prevalence of MRSA and observe the inducible clindamycin resistance (iCR) in S. aureus isolated from clinical samples. By analyzing 45 isolates from wound and blood samples across various hospital departments, the research confirmed 31 (68.9%) MRSA strains via cefoxitin disk diffusion, including a notable prevalence of the mecC gene in 8 isolates. The study also reports iCR through D-tests, revealing that 64.4% of the S. aureus isolates exhibited inducible clindamycin resistance, with a higher occurrence in MRSA than MSSA strains. This highlights the urgency of continued surveillance and advanced molecular techniques to better understand and combat clindamycin resistance in MRSA. Dipita Saha Shweta M.Sc. in Biotechnology 2024-09-25T06:40:06Z 2024-09-25T06:40:06Z ©2024 2024-05 Thesis ID 22276001 http://hdl.handle.net/10361/24189 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 50 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
MRSA mecC Septicemia Methicillin resistant Staphylococcus aureus Inducible Clindamycin resistance Methicillin resistance. Staphylococcus aureus infections. |
| spellingShingle |
MRSA mecC Septicemia Methicillin resistant Staphylococcus aureus Inducible Clindamycin resistance Methicillin resistance. Staphylococcus aureus infections. Shweta, Dipita Saha Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| description |
This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2024. |
| author2 |
Haque, Fahim Kabir Monjurul |
| author_facet |
Haque, Fahim Kabir Monjurul Shweta, Dipita Saha |
| format |
Thesis |
| author |
Shweta, Dipita Saha |
| author_sort |
Shweta, Dipita Saha |
| title |
Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| title_short |
Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| title_full |
Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| title_fullStr |
Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| title_full_unstemmed |
Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh |
| title_sort |
inducible clindamycin resistance among clinically isolated methicillin resistant staphylococcus aureus (mrsa) at tertiary care hospitals in bangladesh |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/24189 |
| work_keys_str_mv |
AT shwetadipitasaha inducibleclindamycinresistanceamongclinicallyisolatedmethicillinresistantstaphylococcusaureusmrsaattertiarycarehospitalsinbangladesh |
| _version_ |
1814308717978451968 |