A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus
A thesis submitted to the School of Pharmacy in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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| Lingua: | English |
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Brac University
2024
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| Accesso online: | http://hdl.handle.net/10361/24057 |
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10361-240572024-09-11T21:01:30Z A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus Jannati, Sadia Zafur Siam,Mohammad Kawsar Sharif School of Pharmacy Monkeypox virus In silico computational tools Vaccine construction Protein Vaccines. Pharmacology. Proteins. A thesis submitted to the School of Pharmacy in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from PDF version of thesis. Includes bibliographical references (pages 40-42). Recently, the number of patients with monkeypox disease is increasing at an alarming rate which has made the necessity of inventing a vaccine against this disease. As a result, this study is performed in order to design a vaccine model against the disease based on in silico computational tools. Scaffold protein OPG 125 has been finalized as the primary protein of this vaccine. CTL, HTL and B cell epitopes are filtered against their antigenic, allergic and toxic elements. The tool Vaxijen v2.0 has identified a 0.5312 antigenic score which has been increased from 0.5352. While evaluating biochemical properties, physical and chemical features were also examined. It shows a negative z score and gravy score which is required for this process. Additionally, 3D model assessment has also been carried out and it provides 80% coverage with a confidence of 100%. In the end molecular docking and immune simulation is performed by using Cluspro and C-ImmSimm. Sadia Zafur Jannati Bachelor of Pharmacy 2024-09-11T06:09:37Z 2024-09-11T06:09:37Z ©2024 2024-04 Thesis ID 20146082 http://hdl.handle.net/10361/24057 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 42 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Monkeypox virus In silico computational tools Vaccine construction Protein Vaccines. Pharmacology. Proteins. |
| spellingShingle |
Monkeypox virus In silico computational tools Vaccine construction Protein Vaccines. Pharmacology. Proteins. Jannati, Sadia Zafur A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| description |
A thesis submitted to the School of Pharmacy in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Siam,Mohammad Kawsar Sharif |
| author_facet |
Siam,Mohammad Kawsar Sharif Jannati, Sadia Zafur |
| format |
Thesis |
| author |
Jannati, Sadia Zafur |
| author_sort |
Jannati, Sadia Zafur |
| title |
A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| title_short |
A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| title_full |
A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| title_fullStr |
A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| title_full_unstemmed |
A novel vaccine designing method using in-silico tools against scaffold protein OPG 125 of monkeypox virus |
| title_sort |
novel vaccine designing method using in-silico tools against scaffold protein opg 125 of monkeypox virus |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/24057 |
| work_keys_str_mv |
AT jannatisadiazafur anovelvaccinedesigningmethodusinginsilicotoolsagainstscaffoldproteinopg125ofmonkeypoxvirus AT jannatisadiazafur novelvaccinedesigningmethodusinginsilicotoolsagainstscaffoldproteinopg125ofmonkeypoxvirus |
| _version_ |
1814307593907077120 |