Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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| التنسيق: | أطروحة |
| اللغة: | English |
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Brac University
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10361/23949 |
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10361-23949 |
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10361-239492024-09-01T21:01:22Z Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies Araf, Faiaz Fahim Mustafa, Nashrah School of Pharmacy, Brac University Dihydrofolate reductase Breast cancer DHFR expression Molecular docking Breast--Cancer Drugs--Computer-aided design This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 53-60). Dihydrofolate Reductase (DHFR) is a critical enzyme linked to tumor development in various cancers, including breast cancer. Breast cancer, a prevalent cancer diagnosed in approximately 2.3 million people each year, arises from complex and unknown mechanisms. This study comprises of a two-part approach. The initial analysis investigated DHFR expression across diverse cancers. The elevated expression of DHFR in breast cancer demonstrated its role in tumorigenesis. Current DHFR inhibitors have a tendency to develop resistance. To address this, the second part of the study utilized molecular docking study with various FDA-approved drugs of different therapeutic classes. With methotrexate as a reference, the study identified clemastine, desloratadine and pexidartinib hydrochloride as potential candidates for breast cancer treatment due to their strong binding affinities to DHFR, superimposition results, amino acid interactions and pharmacokinetic properties. These findings need further validation through molecular dynamic simulation, biological assays and in vivo studies Faiaz Fahim Araf B. Pharmacy 2024-09-01T05:24:43Z 2024-09-01T05:24:43Z ©2024 2024-03 Thesis ID 20146057 http://hdl.handle.net/10361/23949 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 60 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Dihydrofolate reductase Breast cancer DHFR expression Molecular docking Breast--Cancer Drugs--Computer-aided design |
| spellingShingle |
Dihydrofolate reductase Breast cancer DHFR expression Molecular docking Breast--Cancer Drugs--Computer-aided design Araf, Faiaz Fahim Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Mustafa, Nashrah |
| author_facet |
Mustafa, Nashrah Araf, Faiaz Fahim |
| format |
Thesis |
| author |
Araf, Faiaz Fahim |
| author_sort |
Araf, Faiaz Fahim |
| title |
Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| title_short |
Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| title_full |
Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| title_fullStr |
Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| title_full_unstemmed |
Targeting DHFR in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| title_sort |
targeting dhfr in breast cancer: exploring expression patterns and identifying potential inhibitors through docking studies |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23949 |
| work_keys_str_mv |
AT araffaiazfahim targetingdhfrinbreastcancerexploringexpressionpatternsandidentifyingpotentialinhibitorsthroughdockingstudies |
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1814307514130366464 |