Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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Brac University
2024
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| Online dostop: | http://hdl.handle.net/10361/23944 |
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10361-239442024-08-29T21:00:25Z Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer Karim, Samia Binte Azam, Faruque School of Pharmacy, Brac University NSCLC Median age Clinical trial Combination size Clinical trials--Computer simulation Lung--Cancer Therapeutics This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 20-22). Lung cancer is a prominent cause of death annually. It is the most common cancer worldwide and the leading cause of cancer deaths in men and women. In this research, we focused mostly on non-small cell lung cancer (NSCLC) which is the most prevalent subtype. The primary objective of treatment strategies and patient care is to improve quality of life (QoL) and extend survival. Thus, various medications and therapies are being tested in clinical trials. Our evaluation included phase II clinical trial data because it provides a comprehensive and reliable review of safety and effectiveness. A total of 487 data were collected from a sample of 364 papers, comprising 428 overall response rate (ORR) and 374 overall survival (OS) data. To understand patients' survival and response to different treatment sizes, efficacy endpoints were evaluated and differentiated. The relationship between median age, ORR, and OS was examined using correlation analysis. Median age had a weak negative relation with OS, but ORR had a strong positive correlation. Moreover, we found that a combination of three drugs yielded the most beneficial outcome compared to therapy with one or two agents Samia Binte Karim B. Pharmacy 2024-08-29T05:58:04Z 2024-08-29T05:58:04Z ©2024 2023-10 Thesis ID 19304034 http://hdl.handle.net/10361/23944 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 39 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
NSCLC Median age Clinical trial Combination size Clinical trials--Computer simulation Lung--Cancer Therapeutics |
| spellingShingle |
NSCLC Median age Clinical trial Combination size Clinical trials--Computer simulation Lung--Cancer Therapeutics Karim, Samia Binte Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Azam, Faruque |
| author_facet |
Azam, Faruque Karim, Samia Binte |
| format |
Thesis |
| author |
Karim, Samia Binte |
| author_sort |
Karim, Samia Binte |
| title |
Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| title_short |
Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| title_full |
Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| title_fullStr |
Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| title_full_unstemmed |
Pooled analysis of response rate and overall survival of Tyrosine Kinase inhibitor combinations in phase II clinical trials of non-small cell lung cancer |
| title_sort |
pooled analysis of response rate and overall survival of tyrosine kinase inhibitor combinations in phase ii clinical trials of non-small cell lung cancer |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23944 |
| work_keys_str_mv |
AT karimsamiabinte pooledanalysisofresponserateandoverallsurvivaloftyrosinekinaseinhibitorcombinationsinphaseiiclinicaltrialsofnonsmallcelllungcancer |
| _version_ |
1814306894011957248 |