Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020
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Brac University
2024
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| 在線閱讀: | http://hdl.handle.net/10361/23878 |
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10361-238782024-08-22T21:02:21Z Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques Jahan Saiky, Kazi Mustari Alam, Marzia School of Pharmacy, Brac University Aceclofenac Nanoemulsion Ultrasonication Homogenization Anti-inflammatory Smix Nanostructured materials--Congresses. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020 Cataloged from the PDF version of thesis. Includes bibliographical references (pages 26-28). The goal of this study is to evaluate aceclofenac nanoemulsion formulations with varying surfactant-co-surfactant ratio and method of preparation. Aceclofenac is a BCS class II NSAID, with greater anti-inflammatory action than traditional NSAIDS. Ten formulations were prepared in this study, using aceclofenac as the active pharmaceutical ingredient. All 10 formulations contained same amount of aceclofenac, which was 1.5%. Percentage of all the other reagents were kept constant as well except for Tween-80 and ethanol (surfactant and co-surfactant). F1, F2, F3, F4 and F5 were formulated through homogenization method, whereas F1´, F2´, F3´, F4´ and F5´ were formulated through ultrasonication method. All 10 formulations remained stable after 14 days. To further evaluate the formulations, studies like dye test, dilution test, conductivity test, fluorescence test was done. The techniques successfully resulted in 10 stable emulsions, but more studies, e.g. droplet size analysis, zeta potential test, percent transmittance, in-vitro analysis can further confirm if the formulations are nanoemulsions. Kazi Mustari Jahan Saiky B. Pharmacy 2024-08-22T09:09:22Z 2024-08-22T09:09:22Z 2020 2020-02 Thesis ID: 15146097 http://hdl.handle.net/10361/23878 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 28 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Aceclofenac Nanoemulsion Ultrasonication Homogenization Anti-inflammatory Smix Nanostructured materials--Congresses. |
| spellingShingle |
Aceclofenac Nanoemulsion Ultrasonication Homogenization Anti-inflammatory Smix Nanostructured materials--Congresses. Jahan Saiky, Kazi Mustari Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2020 |
| author2 |
Alam, Marzia |
| author_facet |
Alam, Marzia Jahan Saiky, Kazi Mustari |
| format |
Thesis |
| author |
Jahan Saiky, Kazi Mustari |
| author_sort |
Jahan Saiky, Kazi Mustari |
| title |
Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| title_short |
Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| title_full |
Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| title_fullStr |
Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| title_full_unstemmed |
Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| title_sort |
comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23878 |
| work_keys_str_mv |
AT jahansaikykazimustari comparisonandevaluationofaceclofenacnanoemulsionformulationusinghomogenizationandultrasonicationtechniques |
| _version_ |
1814308175174696960 |