A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Idioma: | English |
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Brac University
2024
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| Acesso em linha: | http://hdl.handle.net/10361/23842 |
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10361-238422024-08-21T21:00:30Z A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents Sorno, Rubina Haque Khair, Nishat Zareen School of Pharmacy, Brac University Cyclin dependent kinase 7 CDK- activating kinase CDK7 inhibitors Cell cycle Cancer Cyclin-dependent kinases Cellular immunity Tumors Cancer Microbial cell cycle This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 33-45). Cyclin-dependent kinase 7 (CDK7) is a member of CDK family which is involved in cell cycle progression and transcriptional regulation. Therefore, deregulation of CDK7 has been observed in various types of cancer including ovarian cancer and advanced solid tumors. This potentiates CDK7 as a valid therapeutic target for the treatment of cancer. Thus, selective inhibition of CDK7 can lead to the development of new anticancer therapy with less side effects. However, it is very difficult to selectively inhibit CDK7 as the structure of CDK7 is similar with other CDKs along with the conserved ATP binding site. Despite that, several CDK7 selective inhibitors like SY-5609, Q901, XL102, LGR6768 have reached clinical phases. In this review work, we have compiled updated information on the biology and function of CDK7, its involvement in cancer. Furthermore, we have also studied existing inhibitors of CDK7 which are in various phases of preclinical and clinical trials. Rubina Haque Sorno B. Pharmacy 2024-08-21T04:51:11Z 2024-08-21T04:51:11Z ©2023 2023-12 Thesis ID 18346074 http://hdl.handle.net/10361/23842 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 57 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Cyclin dependent kinase 7 CDK- activating kinase CDK7 inhibitors Cell cycle Cancer Cyclin-dependent kinases Cellular immunity Tumors Cancer Microbial cell cycle |
| spellingShingle |
Cyclin dependent kinase 7 CDK- activating kinase CDK7 inhibitors Cell cycle Cancer Cyclin-dependent kinases Cellular immunity Tumors Cancer Microbial cell cycle Sorno, Rubina Haque A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Khair, Nishat Zareen |
| author_facet |
Khair, Nishat Zareen Sorno, Rubina Haque |
| format |
Thesis |
| author |
Sorno, Rubina Haque |
| author_sort |
Sorno, Rubina Haque |
| title |
A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| title_short |
A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| title_full |
A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| title_fullStr |
A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| title_full_unstemmed |
A review on cyclin-dependent kinase 7 (CDK7) Inhibitors as anticancer agents |
| title_sort |
review on cyclin-dependent kinase 7 (cdk7) inhibitors as anticancer agents |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23842 |
| work_keys_str_mv |
AT sornorubinahaque areviewoncyclindependentkinase7cdk7inhibitorsasanticanceragents AT sornorubinahaque reviewoncyclindependentkinase7cdk7inhibitorsasanticanceragents |
| _version_ |
1814306952275034112 |