A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.
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| Ձևաչափ: | Թեզիս |
| Լեզու: | English |
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Brac University
2024
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| Առցանց հասանելիություն: | http://hdl.handle.net/10361/23695 |
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10361-236952024-07-15T21:00:41Z A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas Hossain, Tamara Omer, Humair Bin MD. School of Pharmacy, Brac University Anticancer drugs Mitochondrial respiratory Drug repurposing Metformin Cancer Type 2 diabetes Antineoplastic agents Drug development This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 46-51). Diabetes mellitus is a public health emergency that is increasing drastically worldwide. In many research findings, it is shown that it causes not only cardiovascular diseases but also increases the risk of cancer. Metformin and sulfonylureas are commonly used drugs in the treatment of type 2 diabetes and recent meta-analysis also emphasizes their effects against various types of cancer like breast cancer, prostate cancer and pancreatic cancer. Metformin activates the AMPK and mTOR pathway and it also blocks the mitochondrial respiratory chain complex. Consequently, metformin inhibit the protein synthesis and cell proliferation of tumor cells. The second generation of sulfonylureas are more potent and also exhibit anticancer effects. Sulfonylureas block K+ ion channels, so depolarization occurs thus activating caspase 12 which activates caspase 3,6,7 thus resulting in tumor cell apoptosis. This review article is significant and is expected to realize a much needed knowledge gap in examining the antineoplastic effects of metformin and sulfonyl ureas for drug repurposing. Tamara Hossain B. Pharmacy 2024-07-15T04:44:43Z 2024-07-15T04:44:43Z ©2024 2024-02 Thesis ID 19346070 http://hdl.handle.net/10361/23695 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 51 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
Anticancer drugs Mitochondrial respiratory Drug repurposing Metformin Cancer Type 2 diabetes Antineoplastic agents Drug development |
| spellingShingle |
Anticancer drugs Mitochondrial respiratory Drug repurposing Metformin Cancer Type 2 diabetes Antineoplastic agents Drug development Hossain, Tamara A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. |
| author2 |
Omer, Humair Bin MD. |
| author_facet |
Omer, Humair Bin MD. Hossain, Tamara |
| format |
Thesis |
| author |
Hossain, Tamara |
| author_sort |
Hossain, Tamara |
| title |
A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| title_short |
A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| title_full |
A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| title_fullStr |
A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| title_full_unstemmed |
A review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| title_sort |
review on potential anticancer properties of antidiabetic drugs: metformin and sulfonylureas |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23695 |
| work_keys_str_mv |
AT hossaintamara areviewonpotentialanticancerpropertiesofantidiabeticdrugsmetforminandsulfonylureas AT hossaintamara reviewonpotentialanticancerpropertiesofantidiabeticdrugsmetforminandsulfonylureas |
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