Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
| Главный автор: | |
|---|---|
| Другие авторы: | |
| Формат: | Диссертация |
| Язык: | English |
| Опубликовано: |
Brac University
2024
|
| Предметы: | |
| Online-ссылка: | http://hdl.handle.net/10361/23684 |
| id |
10361-23684 |
|---|---|
| record_format |
dspace |
| spelling |
10361-236842024-07-11T21:01:05Z Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer Yeasmin, Jahida Kabir,Eva Rahman School of Pharmacy, Brac University HER2 protein Targeted-therapy Drug -resistance Drug repurposing Drug resistance Drug development This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of the thesis. Includes bibliographical references (pages 24-26). According to GLOBOCAN data, 2020, breast cancer (BC) is the leading cause of cancer-related mortalities worldwide, with HER2 positive breast cancer being very prevalent. The rising incidence of HER2 positive breast cancer has led to the search and development of targeted treatment strategies. The currently available targeted therapies have revolutionized treatment strategies. However, despite the remarkable progress in HER2 positive breast cancer management, challenges like drug resistance, and long-term side effects persist and need ongoing research attention. As such, drug repurposing could be a powerful strategy in the search for such compounds and thus enhancing the existing drug pool. Drug repurposing using computational biology was performed in the study, followed by analysis of the docking results, superimposition, assessing non-bonded protein-ligand interactions, and ADME properties were performed to propose potential candidates against HER2 positive breast cancer. Based on the results of this study, doxazosin was selected as a potential candidate to be further explored. Further studies such as MD simulation and biological assays will later need to be performed to validate the results of this study Jahida Yeasmin B. Pharmacy 2024-07-11T06:43:55Z 2024-07-11T06:43:55Z © 2023 2023-09 Thesis ID 19346032 http://hdl.handle.net/10361/23684 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 38 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
HER2 protein Targeted-therapy Drug -resistance Drug repurposing Drug resistance Drug development |
| spellingShingle |
HER2 protein Targeted-therapy Drug -resistance Drug repurposing Drug resistance Drug development Yeasmin, Jahida Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Kabir,Eva Rahman |
| author_facet |
Kabir,Eva Rahman Yeasmin, Jahida |
| format |
Thesis |
| author |
Yeasmin, Jahida |
| author_sort |
Yeasmin, Jahida |
| title |
Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| title_short |
Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| title_full |
Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| title_fullStr |
Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| title_full_unstemmed |
Drug repurposing: search for targeted drug candidates in the treatment of HER2 positive breast cancer |
| title_sort |
drug repurposing: search for targeted drug candidates in the treatment of her2 positive breast cancer |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23684 |
| work_keys_str_mv |
AT yeasminjahida drugrepurposingsearchfortargeteddrugcandidatesinthetreatmentofher2positivebreastcancer |
| _version_ |
1814307375558950912 |