An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies
This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023.
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Brac University
2024
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| Acesso em linha: | http://hdl.handle.net/10361/23622 |
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10361-236222024-08-20T07:02:01Z An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies Hasan, Saikat Haque, Fahim Kabir Monjurul Department of Mathematics and Natural Sciences, Brac University HGPS syndrome Progeria disease Mechanism of progeria Mutation of progeria Cardiovascular phenotype Hutchinson-Gilford progeria syndrome -- Treatment. Progeria -- Molecular biology. This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023. Cataloged from the PDF version of the thesis. Includes bibliographical references (pages 26-30). Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by a premature aging system, which leads to death before 14.6 years due to cardiovascular complications and heart failure. HGPS is connected to the mutation of the LMNA gene encoding the intermediate filament protein lamin A. The most significant genetic connection between Progeria and aging is that telomere shortening ends with every replication cycle. Patients experience severe vascular alterations, mainly loss of muscular smooth muscle cells, calcification, fibrosis, generalized atherosclerosis, and electrical, structural, and functional exceptions in the heart. Unfortunately, treatment is not available for HGPS patients; therefore, scientists are trying to define the molecular mechanism of HGPS that will be helpful for the identification of new treatments and the development of the quality of the patients' lives. This review discusses the current knowledge about the disease, cellular mechanisms, DNA damage, and treatment approaches for patients affected with HGPS. Saikat Hasan M. Biotechnology 2024-06-27T06:30:29Z 2024-06-27T06:30:29Z 2023-12 Thesis ID 22276007 http://hdl.handle.net/10361/23622 en 30 pages application/pdf Brac University |
| institution |
Brac University |
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Institutional Repository |
| language |
English |
| topic |
HGPS syndrome Progeria disease Mechanism of progeria Mutation of progeria Cardiovascular phenotype Hutchinson-Gilford progeria syndrome -- Treatment. Progeria -- Molecular biology. |
| spellingShingle |
HGPS syndrome Progeria disease Mechanism of progeria Mutation of progeria Cardiovascular phenotype Hutchinson-Gilford progeria syndrome -- Treatment. Progeria -- Molecular biology. Hasan, Saikat An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| description |
This thesis is submitted in partial fulfillment of the requirement for the degree of Master of Science in Biotechnology, 2023. |
| author2 |
Haque, Fahim Kabir Monjurul |
| author_facet |
Haque, Fahim Kabir Monjurul Hasan, Saikat |
| format |
Thesis |
| author |
Hasan, Saikat |
| author_sort |
Hasan, Saikat |
| title |
An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| title_short |
An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| title_full |
An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| title_fullStr |
An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| title_full_unstemmed |
An update on Hutchinson-Gilford progeria syndrome: a review of the current state of knowledge in Genetic Etiology, Molecular Pathogenesis, and Emerging Treatment Strategies |
| title_sort |
update on hutchinson-gilford progeria syndrome: a review of the current state of knowledge in genetic etiology, molecular pathogenesis, and emerging treatment strategies |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23622 |
| work_keys_str_mv |
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| _version_ |
1814309157402050560 |