Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Acceso en liña: | http://hdl.handle.net/10361/23403 |
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10361-234032024-06-27T03:50:44Z Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract Taki, Ehtesham Sabet Akter, Raushanara School of Pharmacy, Brac University Phytochemical screening Antioxidant activity Phenolics Lagerstroemia thorelli Anthocyanins--Health aspects. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of the thesis. Includes bibliographical references (pages 62-68). This study was aimed to assess antioxidant and antidiabetic properties of Lagerstroemia thorell since no previous reports on its bioactivity screening were found during extensive literature search. Antioxidant activity was determined using total phenolic acid and total flavonoid content assays, while antidiabetic property was evaluated by α-amylase inhibition assay. The phytochemical screening confirmed the presence of flavonoids, polyphenols, glycosides, tannins, carbohydrates, steroids, and resins in L. thorelli. L. thorelli exhibited strong antidiabetic activity, inhibiting α-amylase by 93.9 ± 3.429% at the highest concentration, closely resembling the standard's (Glimepiride) 95.36 ± 3.345% inhibition rate. Furthermore, the plant exhibited a moderate level of antioxidant activity, with a phenolic acid content of 45.18 ± 4.138 mg GAE/g at the highest concentration. The findings inferred that L. thorelli can be used as a potent antidiabetic agent. However, further in-vivo studies and clinical trials are warranted to use it for the treatment of diabetes. Ehtesham Sabet Taki B. Pharmacy 2024-06-12T08:51:56Z 2024-06-12T08:51:56Z 2023-09 Thesis ID 19346022 http://hdl.handle.net/10361/23403 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 68 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Phytochemical screening Antioxidant activity Phenolics Lagerstroemia thorelli Anthocyanins--Health aspects. |
| spellingShingle |
Phytochemical screening Antioxidant activity Phenolics Lagerstroemia thorelli Anthocyanins--Health aspects. Taki, Ehtesham Sabet Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Akter, Raushanara |
| author_facet |
Akter, Raushanara Taki, Ehtesham Sabet |
| format |
Thesis |
| author |
Taki, Ehtesham Sabet |
| author_sort |
Taki, Ehtesham Sabet |
| title |
Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| title_short |
Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| title_full |
Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| title_fullStr |
Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| title_full_unstemmed |
Investigation of in-vitro antidiabetic and antioxidant properties of Lagerstroemia thorelli leaf extract |
| title_sort |
investigation of in-vitro antidiabetic and antioxidant properties of lagerstroemia thorelli leaf extract |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23403 |
| work_keys_str_mv |
AT takiehteshamsabet investigationofinvitroantidiabeticandantioxidantpropertiesoflagerstroemiathorellileafextract |
| _version_ |
1814309387097866240 |