A review on the potential of repurposing of metformin for colon cancer and breast cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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BRAC University
2024
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| Rochtain ar líne: | http://hdl.handle.net/10361/23296 |
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10361-232962024-06-10T21:00:30Z A review on the potential of repurposing of metformin for colon cancer and breast cancer Oishy, Jannatun Noor Chowdhury, Namara Mariam School of Pharmacy, BRAC University Metformin Drug repurposing Cancer Clinical trials Dose Breast--Cancer--Pathophysiology Drug development Metformin--History This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of the thesis. Includes bibliographical references (pages 36-49). Metformin, a hypoglycemic agent is currently being repurposed for the treatment of different types of cancer due to its pleiotropic functions, affordability, stability at room temperature with long shelf life, broadly favorable safety profile. Several potential mechanisms have been suggested for the ability of metformin to suppress cancer growth in vitro and vivo: activation of LKB1/AMPK pathway, inhibition of cancer cell growth by suppressing mTORC1, inhibition of Generation of ROS, reduction of IGF-1, and IGF-2, inhibition of chronic inflammation, activation of the immune system, modulation of ADORA1, and downregulation of gluconeogenesis in the mitochondria. However, by the in-dept summary and assessment of existing clinical data based on OS, PFS, HR, 95% CI in both CRC and BC, it can be said that metformin exhibits greater promise in CRC patients than the BC patients. The affirmation of the curative effect of metformin for the treatment in cancer will be greatly reinforced by comprehensive randomized clinical investigations on diverse participants. Of note, the data collected suggests that the daily dose of 1500–2000 mg of metformin is well tolerated and multiple clinical trials have reported promising results. Jannatun Noor Oishy B. Pharmacy 2024-06-10T04:56:26Z 2024-06-10T04:56:26Z ©2023 2023-02 Thesis ID 19146086 http://hdl.handle.net/10361/23296 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 63 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Metformin Drug repurposing Cancer Clinical trials Dose Breast--Cancer--Pathophysiology Drug development Metformin--History |
| spellingShingle |
Metformin Drug repurposing Cancer Clinical trials Dose Breast--Cancer--Pathophysiology Drug development Metformin--History Oishy, Jannatun Noor A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Chowdhury, Namara Mariam |
| author_facet |
Chowdhury, Namara Mariam Oishy, Jannatun Noor |
| format |
Thesis |
| author |
Oishy, Jannatun Noor |
| author_sort |
Oishy, Jannatun Noor |
| title |
A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| title_short |
A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| title_full |
A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| title_fullStr |
A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| title_full_unstemmed |
A review on the potential of repurposing of metformin for colon cancer and breast cancer |
| title_sort |
review on the potential of repurposing of metformin for colon cancer and breast cancer |
| publisher |
BRAC University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23296 |
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AT oishyjannatunnoor areviewonthepotentialofrepurposingofmetforminforcoloncancerandbreastcancer AT oishyjannatunnoor reviewonthepotentialofrepurposingofmetforminforcoloncancerandbreastcancer |
| _version_ |
1814306950903496704 |