A review on genotoxicity of different drug molecule
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
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BRAC University
2024
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| Online Access: | http://hdl.handle.net/10361/23219 |
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10361-232192024-06-06T21:02:10Z A review on genotoxicity of different drug molecule Rumi, S.M. Mahmud Jahan Haque, Md. Aminul School of Pharmacy, Brac University Genotoxicity Mutation Toxicity Carcinogenicity Enzymes Impurities Molecule Substance Drugs--Analysis Alkylating agents--Toxicology Chemical mutagenesis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Includes bibliographical references (pages 18-21). In the field of genetics, genotoxicity is a property of chemical compounds that results in mutations by harming a cell’s genetic material. In genetics, it’s also used to define a harmful reaction on a cell’s genetic substance (DNA, RNA) that changes the integrity of the cell. Mutagens are substances that are responsible for mutations. Radiation and chemical genotoxins are both examples of genotoxins. A genotoxin is a substance that possesses the property of genotoxicity. Genotoxic impurities (GTIs) are chemicals that can cause cancer by causing genetic mutations, chromosomal breakage, and/or chromosomal rearrangements. The main issue is that genotoxic substance of drug may trigger somatic mutations or cause cancer. Drug substances are vulnerable to chemical reactions with other components such as excipients or their contaminants, drug substance counter ions, residual solvents, and degradation reaction side-products. This review study focuses on the necessity for genotoxicity, the importance of genotoxicity, genotoxicity mechanisms, genotoxicity testing and genotoxicity evaluation. Besides, this paper also reviews the genotoxicity of some different drug molecule. S.M. Mahmud Jahan Rumi B. Pharmacy 2024-06-06T10:00:00Z 2024-06-06T10:00:00Z ©2022 2022-11 Thesis ID 14346008 http://hdl.handle.net/10361/23219 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 33 pages application/pdf BRAC University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Genotoxicity Mutation Toxicity Carcinogenicity Enzymes Impurities Molecule Substance Drugs--Analysis Alkylating agents--Toxicology Chemical mutagenesis |
| spellingShingle |
Genotoxicity Mutation Toxicity Carcinogenicity Enzymes Impurities Molecule Substance Drugs--Analysis Alkylating agents--Toxicology Chemical mutagenesis Rumi, S.M. Mahmud Jahan A review on genotoxicity of different drug molecule |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. |
| author2 |
Haque, Md. Aminul |
| author_facet |
Haque, Md. Aminul Rumi, S.M. Mahmud Jahan |
| format |
Thesis |
| author |
Rumi, S.M. Mahmud Jahan |
| author_sort |
Rumi, S.M. Mahmud Jahan |
| title |
A review on genotoxicity of different drug molecule |
| title_short |
A review on genotoxicity of different drug molecule |
| title_full |
A review on genotoxicity of different drug molecule |
| title_fullStr |
A review on genotoxicity of different drug molecule |
| title_full_unstemmed |
A review on genotoxicity of different drug molecule |
| title_sort |
review on genotoxicity of different drug molecule |
| publisher |
BRAC University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23219 |
| work_keys_str_mv |
AT rumismmahmudjahan areviewongenotoxicityofdifferentdrugmolecule AT rumismmahmudjahan reviewongenotoxicityofdifferentdrugmolecule |
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1814307826050269184 |