Association of SIRT6 with obesity and diabetes

Association of SIRT6 with obesity and diabetes

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.

Dettagli Bibliografici
Autore principale: Tabassum, Sameha
Altri autori: Akter, Raushanara
Natura: Tesi
Lingua:English
Pubblicazione: BRAC University 2024
Soggetti:
SIRT6
Obesity
Type 2 diabetes
Gluconeogenesis
Overweight persons
Sugars > Metabolism > Disorders
Mammals > Physiology
Accesso online:http://hdl.handle.net/10361/23211
id 10361-23211
record_format dspace
spelling 10361-232112024-06-06T21:03:56Z Association of SIRT6 with obesity and diabetes Tabassum, Sameha Akter, Raushanara School of Pharmacy, BRAC University SIRT6 Obesity Type 2 diabetes Gluconeogenesis Overweight persons Sugars--Metabolism--Disorders Mammals--Physiology This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. Cataloged from the PDF version of the thesis. Includes bibliographical references (pages 50-59). SIRT6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It controls aging, cancer, obesity, insulin resistance, inflammation, and energy metabolism, playing a significant role in both physiological and pathological processes. Sirt6 levels and function diminish with age and overnutrition, two key risk factors for obesity and diabetes, which results in improper glucose and lipid metabolism. Mice with SIRT6 ablation across the body have acute hypoglycemia. SIRT6 deficiency enhances diet-induced obesity and insulin resistance and causes liver steatosis. Diabetes and obesity are protected against SIRT6.This review examines the data supporting SIRT6's emerging function as a regulator of metabolism in mammals and lists its key roles in obesity and diabetes. Sameha Tabassum B. Pharmacy 2024-06-06T08:28:43Z 2024-06-06T08:28:43Z ©2022 2022-11 Thesis ID 18346039 http://hdl.handle.net/10361/23211 en 72 pages application/pdf BRAC University
institution Brac University
collection Institutional Repository
language English
topic SIRT6
Obesity
Type 2 diabetes
Gluconeogenesis
Overweight persons
Sugars--Metabolism--Disorders
Mammals--Physiology
spellingShingle SIRT6
Obesity
Type 2 diabetes
Gluconeogenesis
Overweight persons
Sugars--Metabolism--Disorders
Mammals--Physiology
Tabassum, Sameha
Association of SIRT6 with obesity and diabetes
description This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
author2 Akter, Raushanara
author_facet Akter, Raushanara
Tabassum, Sameha
format Thesis
author Tabassum, Sameha
author_sort Tabassum, Sameha
title Association of SIRT6 with obesity and diabetes
title_short Association of SIRT6 with obesity and diabetes
title_full Association of SIRT6 with obesity and diabetes
title_fullStr Association of SIRT6 with obesity and diabetes
title_full_unstemmed Association of SIRT6 with obesity and diabetes
title_sort association of sirt6 with obesity and diabetes
publisher BRAC University
publishDate 2024
url http://hdl.handle.net/10361/23211
work_keys_str_mv AT tabassumsameha associationofsirt6withobesityanddiabetes
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