Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Lingua: | English |
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Brac University
2024
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| Accesso online: | http://hdl.handle.net/10361/23175 |
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10361-231752024-06-06T21:06:09Z Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract Lihu, Imanul Kabir Akter, Raushanara School of Pharmacy, Brac University Antioxidant Cytotoxic HeLa Lagerstroemia thorelli Antioxidants Cell-mediated cytotoxicity This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 66-72). Lagerstroemia thorelli belongs to the Lythraceae family and is natively known as choto jarul. This study was undertaken to identify the antioxidant and cytotoxic properties of this plant since no previous reports on its bioactivities were found in a thorough literature search. Antioxidant potential was evaluated using H2O2 scavenging activity and total antioxidant capacity (TAC) assays. Cytotoxicity was determined using MTT assay against cervical cancer cell line, HeLa. This plant extract demonstrated strong H2O2 scavenging activity with an IC50 of 2.22 μg/mL, which was close to that of standard ascorbic acid (IC50 =2.84 μg/mL). The TAC was 98.19 ± 3.864 mg AAE/g of dry extract at the highest concentration, 1200 μg/mL. However, the cytotoxicity study on HeLa cell line revealed low cytotoxic activity due to cell line characteristics. Thus, Lagerstreomia thorelli can be used in the treatment of free radical induced diseases due to possessing strong antioxidant activity Imanul Kabir Lihu B. Pharmacy 2024-06-06T03:53:33Z 2024-06-06T03:53:33Z ©2023 2023-09 Thesis ID 19346001 http://hdl.handle.net/10361/23175 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 72 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antioxidant Cytotoxic HeLa Lagerstroemia thorelli Antioxidants Cell-mediated cytotoxicity |
| spellingShingle |
Antioxidant Cytotoxic HeLa Lagerstroemia thorelli Antioxidants Cell-mediated cytotoxicity Lihu, Imanul Kabir Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Akter, Raushanara |
| author_facet |
Akter, Raushanara Lihu, Imanul Kabir |
| format |
Thesis |
| author |
Lihu, Imanul Kabir |
| author_sort |
Lihu, Imanul Kabir |
| title |
Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| title_short |
Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| title_full |
Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| title_fullStr |
Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| title_full_unstemmed |
Investigation of in vitro antioxidant and cytotoxic properties of Lagerstroemia thorelli leaf extract |
| title_sort |
investigation of in vitro antioxidant and cytotoxic properties of lagerstroemia thorelli leaf extract |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23175 |
| work_keys_str_mv |
AT lihuimanulkabir investigationofinvitroantioxidantandcytotoxicpropertiesoflagerstroemiathorellileafextract |
| _version_ |
1814309665912127488 |