Potential treatments for epigenetic dysregulation in neurological diseases
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
| Autor principal: | |
|---|---|
| Altres autors: | |
| Format: | Thesis |
| Idioma: | English |
| Publicat: |
Brac University
2024
|
| Matèries: | |
| Accés en línia: | http://hdl.handle.net/10361/23157 |
| id |
10361-23157 |
|---|---|
| record_format |
dspace |
| spelling |
10361-231572024-06-05T21:00:35Z Potential treatments for epigenetic dysregulation in neurological diseases Zaman, Rubaiyat Sharmin, Sabrina School of Pharmacy, Brac University Epigenetics Methylation Parkinson’s disease Alzheimer’s disease Huntington’s disease Acetylation Nervous System Diseases Epigenesis This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 54-61). Epigenetics is of great importance to modern neuroscience because of its link to the etiology of certain neurodegenerative diseases. The roles of epigenetic changes like DNA methylation and histone acetylation in transcriptional control and dysregulation have been extensively investigated. DNA hypo methylation in Alzheimer's disease leads to elevated presenilin 1 expression, which in turn increases amyloid beta peptide deposition. Increased -synuclein expression and accumulated SNCA protein are hallmarks of Parkinson's disease, which is caused by aberrant methylation. Mutant Huntingtin causes transcriptional dysregulations in Huntington's disease by inhibiting histone acetyltransferases. This project paper reviews on the topic of epigenetics and neurodegeneration and discuss the role that how epigenetic dysregulation plays in the onset of these diseases and offer some insight into the therapeutic potential of epigenetics-based approaches. Rubaiyat Zaman B. Pharmacy 2024-06-05T08:30:25Z 2024-06-05T08:30:25Z ©2023 2023-02 Thesis ID: 19146031 http://hdl.handle.net/10361/23157 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 77 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Epigenetics Methylation Parkinson’s disease Alzheimer’s disease Huntington’s disease Acetylation Nervous System Diseases Epigenesis |
| spellingShingle |
Epigenetics Methylation Parkinson’s disease Alzheimer’s disease Huntington’s disease Acetylation Nervous System Diseases Epigenesis Zaman, Rubaiyat Potential treatments for epigenetic dysregulation in neurological diseases |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Sharmin, Sabrina |
| author_facet |
Sharmin, Sabrina Zaman, Rubaiyat |
| format |
Thesis |
| author |
Zaman, Rubaiyat |
| author_sort |
Zaman, Rubaiyat |
| title |
Potential treatments for epigenetic dysregulation in neurological diseases |
| title_short |
Potential treatments for epigenetic dysregulation in neurological diseases |
| title_full |
Potential treatments for epigenetic dysregulation in neurological diseases |
| title_fullStr |
Potential treatments for epigenetic dysregulation in neurological diseases |
| title_full_unstemmed |
Potential treatments for epigenetic dysregulation in neurological diseases |
| title_sort |
potential treatments for epigenetic dysregulation in neurological diseases |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23157 |
| work_keys_str_mv |
AT zamanrubaiyat potentialtreatmentsforepigeneticdysregulationinneurologicaldiseases |
| _version_ |
1814306950070927360 |