Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.

Bibliographic Details
Main Author:	Hossain, Ragib
Other Authors:	Talukder, Mesbah
Format:	Thesis
Language:	English
Published:	Brac University 2024
Subjects:	Onychomycosis Hepatotoxicity Acute Kidney Injury Hepatotoxicology Acute renal failure
Online Access:	http://hdl.handle.net/10361/23148

id	10361-23148
record_format	dspace
spelling	10361-231482024-06-05T21:06:12Z Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS) Hossain, Ragib Talukder, Mesbah School of Pharmacy, Brac University Onychomycosis Hepatotoxicity Acute Kidney Injury Onychomycosis Hepatotoxicology Acute renal failure This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 24-28). Infections caused by fungi typically affect the skin, nails, and lungs but they can also penetrate the skin, infect the organs and spread throughout the body but research has found that dermatophytosis of the toenails and fingernails, known as onychomycosis, is more challenging to treat with medication than fungal infections of other body parts. Due to their high cure rates and safety profiles, azole antifungals replaced topical treatments in treating onychomycosis. However, studies suggest these medicines cause Hepatotoxicity and Acute kidney injury. In this study information from the FAERS database is analyzed using a reporting odds ratio (ROR) to identify potential danger signs. Hepatotoxicity Reporting odds ratio for drug's were, Voriconazole 8.16 (6.29, 10.60) > Itraconazole 3.98 (1.99, 7.96) > Posaconazole 3.23 (1.62, 6.47). Additionally, Acute kidney Injury Reporting odds ratio for selected drug were, Voriconazole 0.46 (0.33, 0.65) > Posaconazole 0.37 (0.19, 0.71) > Itraconazole 0.10 (0.03, 0.40). Ragib Hossain B. Pharmacy 2024-06-05T06:08:23Z 2024-06-05T06:08:23Z ©2023 2023-02 Thesis ID 19146002 http://hdl.handle.net/10361/23148 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 40 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	Onychomycosis Hepatotoxicity Acute Kidney Injury Onychomycosis Hepatotoxicology Acute renal failure
spellingShingle	Onychomycosis Hepatotoxicity Acute Kidney Injury Onychomycosis Hepatotoxicology Acute renal failure Hossain, Ragib Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
description	This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
author2	Talukder, Mesbah
author_facet	Talukder, Mesbah Hossain, Ragib
format	Thesis
author	Hossain, Ragib
author_sort	Hossain, Ragib
title	Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
title_short	Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
title_full	Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
title_fullStr	Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
title_full_unstemmed	Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)
title_sort	hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of onychomycosis: pharmacovigilance study of fda adverse event reporting system data (faers)
publisher	Brac University
publishDate	2024
url	http://hdl.handle.net/10361/23148
work_keys_str_mv	AT hossainragib hepatotoxicityandacutekidneyinjuryassociationswithitraconazolevoriconazoleandposaconazoleinthetreatmentofonychomycosispharmacovigilancestudyoffdaadverseeventreportingsystemdatafaers
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Hepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)

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