A review on RNAi technology and its therapeutic potential in Cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Rochtain ar líne: | http://hdl.handle.net/10361/23139 |
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10361-231392024-06-05T21:01:38Z A review on RNAi technology and its therapeutic potential in Cancer Mahaleka, Aarshi Khan, Tanisha Tabassum Sayka School of Pharmacy, Brac University RNAi technology Gene silencing siRNA shRNA miRNA Cancer Cancer--Gene therapy Gene silencing MicroRNA Small interfering RNA This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 36-39). Cancer is still considered as the major global cause of death. RNAi technology serves as one of the tools to treat cancer with its strategies, designs and delivery methods. This gene silencing technique causes knockdown of genes that encodes for diseased proteins or prevents overexpression of genes. Cancer development and progression occurs as a result of overactivation of different signaling pathways involved in cell proliferation, cell differentiation and cell survival. There are several proteins acting as signaling molecules which can induce cancer from their overproduction. Mutation can also lead to activation of oncogenes that codes for cancer causing proteins. To inhibit the production of the responsible protein in cancer, RNAi gene silencing technique is utilized with siRNA, shRNA and mRNA via degradation of the target mRNA responsible for the disease. This review paper provides an insight on the concept of RNAi technology and its therapeutic potential in different types of cancer. Aarshi Mahaleka B. Pharmacy 2024-06-05T05:12:10Z 2024-06-05T05:12:10Z ©2023 2023-02 Thesis ID: 19146053 http://hdl.handle.net/10361/23139 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 52 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
RNAi technology Gene silencing siRNA shRNA miRNA Cancer Cancer--Gene therapy Gene silencing MicroRNA Small interfering RNA |
| spellingShingle |
RNAi technology Gene silencing siRNA shRNA miRNA Cancer Cancer--Gene therapy Gene silencing MicroRNA Small interfering RNA Mahaleka, Aarshi A review on RNAi technology and its therapeutic potential in Cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Khan, Tanisha Tabassum Sayka |
| author_facet |
Khan, Tanisha Tabassum Sayka Mahaleka, Aarshi |
| format |
Thesis |
| author |
Mahaleka, Aarshi |
| author_sort |
Mahaleka, Aarshi |
| title |
A review on RNAi technology and its therapeutic potential in Cancer |
| title_short |
A review on RNAi technology and its therapeutic potential in Cancer |
| title_full |
A review on RNAi technology and its therapeutic potential in Cancer |
| title_fullStr |
A review on RNAi technology and its therapeutic potential in Cancer |
| title_full_unstemmed |
A review on RNAi technology and its therapeutic potential in Cancer |
| title_sort |
review on rnai technology and its therapeutic potential in cancer |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23139 |
| work_keys_str_mv |
AT mahalekaaarshi areviewonrnaitechnologyanditstherapeuticpotentialincancer AT mahalekaaarshi reviewonrnaitechnologyanditstherapeuticpotentialincancer |
| _version_ |
1814307590395396096 |