Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Acesso em linha: | http://hdl.handle.net/10361/23114 |
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10361-231142024-06-04T21:02:11Z Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies Mim, Md. Rasel Mahmud Omer, Humair Bin Md School of Pharmacy, Brac University Sharpless asymmetric epoxidation Asymmetric dihydroxylation Chiral photochemical synthesis Hypertension. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 59-66). Nebivolol is a potent beta-blocker used to treat heart failure and hypertension. With the increasing prevalence of cardiovascular diseases and the demand for effective and well-tolerated treatments, the global market for beta-blockers, including nebivolol, was worth approximately US$8.5 billion in 2020 and is projected to grow by 5.5% in the coming years. There are several techniques for synthesizing nebivolol, including Sharpless asymmetric epoxidation, Pd-, Zr-, and Mo-catalyzed processes, photochemical reconfiguration, and homochiral sulfoxide-directed reaction (Jiang et al., 2021). Among these techniques, Zr- and Mo-catalyzed processes produce the highest efficiency of 99%. However, using natural chiral starting materials and Sharpless asymmetric epoxidation is more efficient in terms of time and cost. This review article provides an in-depth analysis of the effectiveness of the various nebivolol synthesis techniques. The commercial expansion of beta-blockers and the rising need for efficient and well-tolerated medicines emphasize how critical it is to conduct further research in this area. Md. Rasel Mahmud Mim B. Pharmacy 2024-06-04T06:51:04Z 2024-06-04T06:51:04Z 2023 2023-02 Thesis ID 19146081 http://hdl.handle.net/10361/23114 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 66 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Sharpless asymmetric epoxidation Asymmetric dihydroxylation Chiral photochemical synthesis Hypertension. |
| spellingShingle |
Sharpless asymmetric epoxidation Asymmetric dihydroxylation Chiral photochemical synthesis Hypertension. Mim, Md. Rasel Mahmud Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Omer, Humair Bin Md |
| author_facet |
Omer, Humair Bin Md Mim, Md. Rasel Mahmud |
| format |
Thesis |
| author |
Mim, Md. Rasel Mahmud |
| author_sort |
Mim, Md. Rasel Mahmud |
| title |
Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| title_short |
Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| title_full |
Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| title_fullStr |
Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| title_full_unstemmed |
Synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| title_sort |
synthesis and characterization of nebivolol: a review of different synthetic approaches and their efficiencies |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23114 |
| work_keys_str_mv |
AT mimmdraselmahmud synthesisandcharacterizationofnebivololareviewofdifferentsyntheticapproachesandtheirefficiencies |
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1814308094602117120 |